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  • Eranti, AnttiNorth Karelia Central Hospital (författare)

Orthogonal P-wave morphology, conventional P-wave indices, and the risk of atrial fibrillation in the general population using data from the Finnish Hospital Discharge Register

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-06-18
  • Oxford University Press (OUP),2020
  • 9 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:9fca825f-7976-45f1-9798-83be9faca94b
  • https://lup.lub.lu.se/record/9fca825f-7976-45f1-9798-83be9faca94bURI
  • https://doi.org/10.1093/europace/euaa118DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • AIMS: Identifying subjects at high and low risk of atrial fibrillation (AF) is of interest. This study aims to assess the risk of AF associated with electrocardiographic (ECG) markers linked to atrial fibrosis: P-wave prolongation, 3rd-degree interatrial block, P-terminal force in lead V1, and orthogonal P-wave morphology. METHODS AND RESULTS: P-wave parameters were assessed in a representative Finnish population sample aged ≥30 years (n = 7217, 46.0% male, mean age 51.4 years). Subjects (n = 5489) with a readable ECG including the orthogonal leads, sinus rhythm, and a predefined orthogonal P-wave morphology type [positive in leads X and Y and either negative (Type 1) or ± biphasic (Type 2) in lead Z; Type 3 defined as positive in lead X and ± biphasic in lead Y], were followed 10 years from the baseline examinations (performed 1978-80). Subjects discharged with AF diagnosis after any-cause hospitalization (n = 124) were defined as having developed AF. Third-degree interatrial block was defined as P-wave ≥120 ms and the presence of ≥2 ± biphasic P waves in the inferior leads. Hazard ratios (HRs) and confidence intervals (CIs) were assessed with Cox models. Third-degree interatrial block (n = 103, HR 3.18, 95% CI 1.66-6.13; P = 0.001) and Type 3 morphology (n = 216, HR 3.01, 95% CI 1.66-5.45; P < 0.001) were independently associated with the risk of hospitalization with AF. Subjects with P-wave <110 ms and Type 1 morphology (n = 2074) were at low risk (HR 0.46, 95% CI 0.26-0.83; P = 0.006), compared to the rest of the subjects. CONCLUSION: P-wave parameters associate with the risk of hospitalization with AF.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Carlson, JonasLund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)kard-jca (författare)
  • Kenttä, TuomasOulu University Hospital,University of Oulu (författare)
  • Holmqvist, FredrikLund University,Lunds universitet,Clinical studies af Atrial Fibrillation,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-fho (författare)
  • Holkeri, ArttuHelsinki University Central Hospital,University of Helsinki (författare)
  • Haukilahti, M. AnetteUniversity of Oulu,Oulu University Hospital (författare)
  • Kerola, TuomasPäijät-Häme Central Hospital (författare)
  • Aro, Aapo L.Helsinki University Central Hospital,University of Helsinki (författare)
  • Rissanen, HarriFinnish National Institute for Health and Welfare (författare)
  • Noponen, KaiUniversity of Oulu (författare)
  • Seppänen, TapioUniversity of Oulu (författare)
  • Knekt, PaulFinnish National Institute for Health and Welfare (författare)
  • Heliövaara, MarkkuFinnish National Institute for Health and Welfare (författare)
  • Huikuri, Heikki V.University of Oulu,Oulu University Hospital (författare)
  • Junttila, M. JuhaniUniversity of Oulu,Oulu University Hospital (författare)
  • Platonov, Pyotr G.Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-ppl (författare)
  • North Karelia Central HospitalElectrocardiology Research Group - CIEL (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology: Oxford University Press (OUP)22:8, s. 1173-11811532-2092
  • Ingår i:EP Europace: Oxford University Press (OUP)22:8, s. 1173-11811099-5129

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