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Gene-centric Meta-a...
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.
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Tragante, Vinicius (author)
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Barnes, Michael R (author)
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Ganesh, Santhi K (author)
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show more...
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Lanktree, Matthew B (author)
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Guo, Wei (author)
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Franceschini, Nora (author)
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Smith, Erin N (author)
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Johnson, Toby (author)
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Holmes, Michael V (author)
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Padmanabhan, Sandosh (author)
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Karczewski, Konrad J (author)
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Almoguera, Berta (author)
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Barnard, John (author)
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Baumert, Jens (author)
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Chang, Yen-Pei Christy (author)
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Elbers, Clara C (author)
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Farrall, Martin (author)
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Fischer, Mary E (author)
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Gaunt, Tom R (author)
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Gho, Johannes M I H (author)
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Gieger, Christian (author)
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Goel, Anuj (author)
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Gong, Yan (author)
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Isaacs, Aaron (author)
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Kleber, Marcus E (author)
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Leach, Irene Mateo (author)
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McDonough, Caitrin W (author)
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Meijs, Matthijs F L (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Nelson, Christopher P (author)
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Nolte, Ilja M (author)
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Pankratz, Nathan (author)
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Price, Tom S (author)
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Shaffer, Jonathan (author)
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Shah, Sonia (author)
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Tomaszewski, Maciej (author)
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van der Most, Peter J (author)
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Van Iperen, Erik P A (author)
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Vonk, Judith M (author)
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Witkowska, Kate (author)
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Wong, Caroline O L (author)
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Zhang, Li (author)
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Beitelshees, Amber L (author)
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Berenson, Gerald S (author)
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Bhatt, Deepak L (author)
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Brown, Morris (author)
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Burt, Amber (author)
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Cooper-Dehoff, Rhonda M (author)
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Connell, John M (author)
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Cruickshanks, Karen J (author)
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Curtis, Sean P (author)
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Davey-Smith, George (author)
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Delles, Christian (author)
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Gansevoort, Ron T (author)
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Guo, Xiuqing (author)
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Haiqing, Shen (author)
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Hastie, Claire E (author)
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Hofker, Marten H (author)
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Hovingh, G Kees (author)
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Kim, Daniel S (author)
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Kirkland, Susan A (author)
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Klein, Barbara E (author)
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Klein, Ronald (author)
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Li, Yun R (author)
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Maiwald, Steffi (author)
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Newton-Cheh, Christopher (author)
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O'Brien, Eoin T (author)
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Onland-Moret, N Charlotte (author)
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Palmas, Walter (author)
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Parsa, Afshin (author)
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Penninx, Brenda W (author)
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Pettinger, Mary (author)
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Vasan, Ramachandran S (author)
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Ranchalis, Jane E (author)
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M Ridker, Paul (author)
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Rose, Lynda M (author)
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Sever, Peter (author)
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Shimbo, Daichi (author)
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Steele, Laura (author)
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Stolk, Ronald P (author)
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Thorand, Barbara (author)
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Trip, Mieke D (author)
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van Duijn, Cornelia M (author)
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Verschuren, W Monique (author)
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Wijmenga, Cisca (author)
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Wyatt, Sharon (author)
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Young, J Hunter (author)
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Zwinderman, Aeilko H (author)
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Bezzina, Connie R (author)
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Boerwinkle, Eric (author)
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Casas, Juan P (author)
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Caulfield, Mark J (author)
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Chakravarti, Aravinda (author)
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Chasman, Daniel I (author)
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Davidson, Karina W (author)
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Doevendans, Pieter A (author)
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Dominiczak, Anna F (author)
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Fitzgerald, Garret A (author)
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Gums, John G (author)
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Fornage, Myriam (author)
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Hakonarson, Hakon (author)
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Halder, Indrani (author)
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Hillege, Hans L (author)
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Illig, Thomas (author)
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Jarvik, Gail P (author)
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Johnson, Julie A (author)
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Kastelein, John J P (author)
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Koenig, Wolfgang (author)
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Kumari, Meena (author)
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März, Winfried (author)
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Murray, Sarah S (author)
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O'Connell, Jeffery R (author)
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Oldehinkel, Albertine J (author)
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Pankow, James S (author)
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Rader, Daniel J (author)
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Redline, Susan (author)
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Reilly, Muredach P (author)
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Schadt, Eric E (author)
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Kottke-Marchant, Kandice (author)
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Snieder, Harold (author)
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Snyder, Michael (author)
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Stanton, Alice V (author)
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Tobin, Martin D (author)
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Uitterlinden, André G (author)
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van der Harst, Pim (author)
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van der Schouw, Yvonne T (author)
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Samani, Nilesh J (author)
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Watkins, Hugh (author)
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Johnson, Andrew D (author)
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Reiner, Alex P (author)
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Zhu, Xiaofeng (author)
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de Bakker, Paul I W (author)
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Levy, Daniel (author)
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Asselbergs, Folkert W (author)
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Munroe, Patricia B (author)
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Keating, Brendan J (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297. ; 94:3, s. 349-360
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tragante, Vinici ...
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Barnes, Michael ...
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Ganesh, Santhi K
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Lanktree, Matthe ...
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Guo, Wei
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Franceschini, No ...
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show more...
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Smith, Erin N
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Johnson, Toby
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Holmes, Michael ...
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Padmanabhan, San ...
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Karczewski, Konr ...
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Almoguera, Berta
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Barnard, John
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Baumert, Jens
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Chang, Yen-Pei C ...
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Elbers, Clara C
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Farrall, Martin
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Fischer, Mary E
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Gaunt, Tom R
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Gho, Johannes M ...
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Gieger, Christia ...
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Goel, Anuj
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Gong, Yan
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Isaacs, Aaron
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Kleber, Marcus E
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Leach, Irene Mat ...
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McDonough, Caitr ...
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Meijs, Matthijs ...
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Melander, Olle
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Nelson, Christop ...
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Nolte, Ilja M
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Pankratz, Nathan
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Price, Tom S
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Shaffer, Jonatha ...
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Shah, Sonia
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Tomaszewski, Mac ...
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van der Most, Pe ...
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Van Iperen, Erik ...
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Vonk, Judith M
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Witkowska, Kate
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Wong, Caroline O ...
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Zhang, Li
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Beitelshees, Amb ...
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Berenson, Gerald ...
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Bhatt, Deepak L
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Brown, Morris
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Burt, Amber
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Cooper-Dehoff, R ...
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Connell, John M
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Cruickshanks, Ka ...
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Curtis, Sean P
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Davey-Smith, Geo ...
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Delles, Christia ...
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Gansevoort, Ron ...
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Guo, Xiuqing
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Haiqing, Shen
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Hastie, Claire E
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Hofker, Marten H
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Hovingh, G Kees
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Kim, Daniel S
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Kirkland, Susan ...
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Klein, Barbara E
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Klein, Ronald
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Li, Yun R
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Maiwald, Steffi
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Newton-Cheh, Chr ...
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O'Brien, Eoin T
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Onland-Moret, N ...
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Palmas, Walter
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Parsa, Afshin
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Penninx, Brenda ...
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Pettinger, Mary
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Vasan, Ramachand ...
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Ranchalis, Jane ...
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M Ridker, Paul
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Rose, Lynda M
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Sever, Peter
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Shimbo, Daichi
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Steele, Laura
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Stolk, Ronald P
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Thorand, Barbara
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Trip, Mieke D
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van Duijn, Corne ...
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Verschuren, W Mo ...
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Wijmenga, Cisca
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Wyatt, Sharon
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Young, J Hunter
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Zwinderman, Aeil ...
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Bezzina, Connie ...
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Boerwinkle, Eric
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Casas, Juan P
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Caulfield, Mark ...
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Chakravarti, Ara ...
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Chasman, Daniel ...
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Davidson, Karina ...
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Doevendans, Piet ...
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Dominiczak, Anna ...
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Fitzgerald, Garr ...
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Gums, John G
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Fornage, Myriam
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Hakonarson, Hako ...
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Halder, Indrani
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Hillege, Hans L
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Illig, Thomas
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Jarvik, Gail P
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Johnson, Julie A
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Kastelein, John ...
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Koenig, Wolfgang
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Kumari, Meena
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März, Winfried
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Murray, Sarah S
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O'Connell, Jeffe ...
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Oldehinkel, Albe ...
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Pankow, James S
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Rader, Daniel J
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Redline, Susan
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Reilly, Muredach ...
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Schadt, Eric E
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Kottke-Marchant, ...
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Snieder, Harold
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Snyder, Michael
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Stanton, Alice V
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Tobin, Martin D
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Uitterlinden, An ...
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van der Harst, P ...
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van der Schouw, ...
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Samani, Nilesh J
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Watkins, Hugh
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Johnson, Andrew ...
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Reiner, Alex P
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Zhu, Xiaofeng
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de Bakker, Paul ...
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Levy, Daniel
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Asselbergs, Folk ...
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Munroe, Patricia ...
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Keating, Brendan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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American Journal ...
- By the university
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Lund University