id:"swepub:oai:lup.lub.lu.se:a023f3f4-aded-4434-8964-e3911bb8fc73"
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- Planck, TerezaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups (author)
Liothyronine Use in Hypothyroidism and its Effects on Cancer and Mortality
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- Mary Ann Liebert Inc,2021
- 8 s.
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- LIBRIS-ID:oai:lup.lub.lu.se:a023f3f4-aded-4434-8964-e3911bb8fc73
- https://lup.lub.lu.se/record/a023f3f4-aded-4434-8964-e3911bb8fc73URI
- https://doi.org/10.1089/thy.2020.0388DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:145555759URI
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- Language:English
- Summary in:English
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- Background: The prescription of liothyronine (LT3) to treat hypothyroidism is increasing worldwide; however, the long-term safety of LT3 use has yet to be determined. Previous studies have suggested a possible association between LT3 use and breast cancer. The aim of this study was to examine the effects of LT3 use on cancer incidence and mortality. Methods: Our sample included the full adult population of individuals living in Sweden with at least three purchases of thyroid hormone therapy between July 2005 and December 2017. Individual-level data on drug purchases were linked to registry data on cancer incidence and mortality. There were 575,461 individuals with at least three purchases, of which 11,147 had made at least three purchases of LT3, including combinations of levothyroxine (LT4) and LT3. Individuals were followed for a median follow-up time of 8.1 years. We applied Cox regression with a time-varying exposure variable, comparing LT3 users (individuals with at least three cumulative purchases of LT3) with LT4-only users (the rest). Outcomes included breast cancer incidence, any cancer incidence, all-cause mortality, any cancer mortality, and breast cancer mortality. We adjusted for age, sex, previous thyroid cancer, previous other cancer, use of antithyroid preparations, use of sex hormones, and dose in multivariate analyses. Results: Multivariate analyses produced a hazard ratio of 0.93 (95% confidence interval [0.75-1.15]) for breast cancer incidence (only females), 0.97 (0.87-1.08) for any cancer incidence, 0.69 (0.61-0.77) for all-cause mortality, 0.78 (0.62-0.98) for any cancer mortality, and 0.91 (0.50-1.66) for breast cancer mortality (only females). Conclusions: In this large, Swedish, long-term registry-based study, the use of LT3 did not lead to increased breast cancer incidence, any cancer incidence, all-cause mortality, any cancer mortality, or breast cancer mortality compared with LT4 use. Somewhat surprisingly, there was evidence of lower mortality in LT3 users in models adjusting for dose, potentially an artifact of underlying associations between dose and health status/diagnosis.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- breast cancer
- cancer
- hypothyroidism
- levothyroxine
- liothyronine
- mortality
- triiodothyronine
Added entries (persons, corporate bodies, meetings, titles ...)
- Hedberg, FredricKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (author)
- Calissendorff, JanKarolinska Institutet,Karolinska Institute,Karolinska University Hospital (author)
- Nilsson, AntonLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,EPI@LUND,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups(Swepub:lu)nek-anl (author)
- Translationell muskelforskningForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Thyroid: Mary Ann Liebert Inc31:5, s. 732-7391050-72561557-9077
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