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- Gradowski, MarcinWarsaw University of Life Sciences (author)
The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-09-26
- PeerJ,2017
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:a1a5a1a5-db2a-4004-a515-d4e2a4d9d33f
- https://lup.lub.lu.se/record/a1a5a1a5-db2a-4004-a515-d4e2a4d9d33fURI
- https://doi.org/10.7717/peerj.3849DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
- Bacterial effectors
- Mitochondrial carriers
- Proteases
- Structure prediction
Added entries (persons, corporate bodies, meetings, titles ...)
- Pawlowski, KrzysztofLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för translationell medicin,Clinical Protein Science and Imaging,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Translational Medicine,Lund University Research Groups,Warsaw University of Life Sciences(Swepub:lu)med-kzp (author)
- Warsaw University of Life SciencesInstitutionen för kliniska vetenskaper, Lund (creator_code:org_t)
Related titles
- In:PeerJ: PeerJ2017:92167-8359
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