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Effects of Levodopa...
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Chaudhuri, K. RayKing's College Hospital
(författare)
Effects of Levodopa-Carbidopa Intestinal Gel on Dyskinesia and Non-Motor Symptoms Including Sleep : Results from a Meta-Analysis with 24-Month Follow-Up
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:a1bf102d-1110-4a13-92b0-197aa5f700af
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https://lup.lub.lu.se/record/a1bf102d-1110-4a13-92b0-197aa5f700afURI
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https://doi.org/10.3233/JPD-223295DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: In advanced Parkinson's disease (PD), dyskinesias and non-motor symptoms such as sleep dysfunction can significantly impair quality of life, and high-quality management is an unmet need. Objective: To analyze changes in dyskinesia and non-motor symptoms (including sleep) among studies with levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Methods: A comprehensive literature review identified relevant studies examining LCIG efficacy. Outcomes of interest were dyskinesia (UDysRS, UPDRS IV item 32), overall non-motor symptoms (NMSS), mentation/behavior/mood (UPDRS I), and sleep/daytime sleepiness (PDSS-2, ESS). The pooled mean (95% confidence interval) change from baseline per outcome was estimated for each 3-month interval with sufficient data (i.e., reported by≥3 studies) up to 24 months using a random-effects model. Results: Seventeen open-label studies evaluating 1243 patients with advanced PD were included. All outcomes of interest with sufficient data for meta-analysis showed statistically significant improvement within 6 months of starting LCIG. There were statistically significant improvements in dyskinesia duration as measured by UPDRS IV item 32 at 6 months (-1.10 [-1.69, -0.51] h/day) and 12 months (-1.35 [-2.07, -0.62] h/day). There were statistically and clinically significant improvements in non-motor symptoms as measured by NMSS scores at 3 months (-28.71 [-40.26, -17.15] points). Significant reduction of NMSS burden was maintained through 24 months (-17.61 [-21.52, -13.70] points). UPDRS I scores significantly improved at 3 months (-0.39 [-0.55, -0.22] points). Clinically significant improvements in PDSS-2 and ESS scores were observed at 6 and 12 months in individual studies. Conclusion: Patients with advanced PD receiving LCIG showed significant sustained improvements in the burden of dyskinesia and non-motor symptoms up to 24 months after initiation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Antonini, AngeloUniversity of Padova
(författare)
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Pahwa, RajeshUniversity of Kansas Medical Center
(författare)
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Odin, PerLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-poi
(författare)
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Titova, NataliyaFederal Center of Brain Research and Neurotechnologies of the FMBA of Russia,Pirogov Russian National Research Medical University (RNRMU)
(författare)
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Thakkar, SandeepHoag Hospital Newport Beach
(författare)
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Snedecor, Sonya J.Open Health, New York
(författare)
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Hegde, SaketOpen Health, New York
(författare)
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Alobaidi, AliUniversity of Illinois at Chicago,AbbVie Inc.
(författare)
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Parra, Juan CarlosAbbVie Inc.
(författare)
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Zadikoff, CindyAbbVie Inc.
(författare)
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Bergmann, LarsAbbVie Inc.
(författare)
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Standaert, David G.University of Alabama
(författare)
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King's College HospitalUniversity of Padova
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Parkinson's Disease12:7, s. 2071-20831877-7171
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Chaudhuri, K. Ra ...
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Antonini, Angelo
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Pahwa, Rajesh
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Odin, Per
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Titova, Nataliya
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Thakkar, Sandeep
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visa fler...
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Snedecor, Sonya ...
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Hegde, Saket
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Alobaidi, Ali
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Parra, Juan Carl ...
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Zadikoff, Cindy
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Bergmann, Lars
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Standaert, David ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Journal of Parki ...
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Lunds universitet