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Reactive oxygen spe...
Reactive oxygen species in renal vascular function
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- Xu, Nan (författare)
- Zhejiang Univ, Dept Physiol, Sch Med, Hangzhou, Peoples R China.
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- Jiang, Shan (författare)
- Zhejiang Univ, Dept Physiol, Sch Med, Hangzhou, Peoples R China.
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- Persson, Pontus B. (författare)
- Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.;Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.;Berlin Inst Hlth, Inst Vegetat Physiol, Charitepl 1, D-10117 Berlin, Germany.
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- Persson, Erik A.G. (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Lai, En Yin (författare)
- Zhejiang Univ, Dept Physiol, Sch Med, Hangzhou, Peoples R China.;Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.;Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.;Berlin Inst Hlth, Inst Vegetat Physiol, Charitepl 1, D-10117 Berlin, Germany.
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- Patzak, Andreas (författare)
- Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.;Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.;Berlin Inst Hlth, Inst Vegetat Physiol, Charitepl 1, D-10117 Berlin, Germany.
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Zhejiang Univ, Dept Physiol, Sch Med, Hangzhou, Peoples R China Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.;Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.;Berlin Inst Hlth, Inst Vegetat Physiol, Charitepl 1, D-10117 Berlin, Germany. (creator_code:org_t)
- 2020-05-08
- 2020
- Engelska.
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Ingår i: Acta Physiologica. - : WILEY. - 1748-1708 .- 1748-1716. ; 229:4
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Reactive oxygen species (ROS) are produced by the aerobic metabolism. The imbalance between production of ROS and antioxidant defence in any cell compartment is associated with cell damage and may play an important role in the pathogenesis of renal disease. NADPH oxidase (NOX) family is the major ROS source in the vasculature and modulates renal perfusion. Upregulation of Ang II and adenosine activates NOX via AT1R and A1R in renal microvessels, leading to superoxide production. Oxidative stress in the kidney prompts renal vascular remodelling and increases preglomerular resistance. These are key elements in hypertension, acute and chronic kidney injury, as well as diabetic nephropathy. Renal afferent arterioles (Af), the primary resistance vessel in the kidney, fine tune renal hemodynamics and impact on blood pressure. Vice versa, ROS increase hypertension and diabetes, resulting in upregulation of Af vasoconstriction, enhancement of myogenic responses and change of tubuloglomerular feedback (TGF), which further promotes hypertension and diabetic nephropathy. In the following, we highlight oxidative stress in the function and dysfunction of renal hemodynamics. The renal microcirculatory alterations brought about by ROS importantly contribute to the pathophysiology of kidney injury, hypertension and diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- afferent arteriole
- hypertension
- reactive oxygen species
- renal microvasculature
- vasa recta
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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