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A Comparison of Rul...
A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study
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Haghighi, Mona (author)
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- Johnson, Suzanne Bennett (author)
- Florida State University
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- Qian, Xiaoning (author)
- Texas A and M University
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show more...
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- Lynch, Kristian F. (author)
- University of South Florida
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- Vehik, Kendra (author)
- University of South Florida
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Huang, Shuai (author)
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Rewers, Marian (author)
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Barriga, Katherine (author)
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Baxter, Judith (author)
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Eisenbarth, George (author)
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Frank, Nicole (author)
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Gesualdo, Patricia (author)
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Hoffman, Michelle (author)
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Norris, Jill (author)
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Ide, Lisa (author)
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Robinson, Jessie (author)
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Waugh, Kathleen (author)
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She, Jin Xiong (author)
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Schatz, Desmond (author)
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Hopkins, Diane (author)
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Steed, Leigh (author)
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Choate, Angela (author)
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Silvis, Katherine (author)
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Shankar, Meena (author)
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Huang, Yi Hua (author)
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Yang, Ping (author)
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Wang, Hong Jie (author)
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Leggett, Jessica (author)
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English, Kim (author)
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McIndoe, Richard (author)
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Dequesada, Angela (author)
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Haller, Michael (author)
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Anderson, Stephen W. (author)
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Ziegler, Anette G. (author)
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Boerschmann, Heike (author)
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Bonifacio, Ezio (author)
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Bunk, Melanie (author)
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Försch, Johannes (author)
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Henneberger, Lydia (author)
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Hummel, Michael (author)
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Hummel, Sandra (author)
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Joslowski, Gesa (author)
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Kersting, Mathilde (author)
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Knopff, Annette (author)
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Kocher, Nadja (author)
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Koletzko, Sibylle (author)
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Krause, Stephanie (author)
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Lauber, Claudia (author)
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Mollenhauer, Ulrike (author)
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Peplow, Claudia (author)
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Pflüger, Maren (author)
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Pöhlmann, Daniela (author)
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Ramminger, Claudia (author)
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Rash-Sur, Sargol (author)
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Roth, Roswith (author)
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Schenkel, Julia (author)
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Thümer, Leonore (author)
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Voit, Katja (author)
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Winkler, Christiane (author)
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Zwilling, Marina (author)
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- Simell, Olli G. (author)
- Finnish National Institute for Health and Welfare
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- Nanto-Salonen, Kirsti (author)
- Finnish National Institute for Health and Welfare
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- Ilonen, Jorma (author)
- Finnish National Institute for Health and Welfare
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- Knip, Mikael (author)
- Finnish National Institute for Health and Welfare
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- Veijola, Riitta (author)
- Finnish National Institute for Health and Welfare
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- Simell, Tuula (author)
- Finnish National Institute for Health and Welfare
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- Hyöty, Heikki (author)
- Finnish National Institute for Health and Welfare
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- Virtanen, Suvi M. (author)
- Finnish National Institute for Health and Welfare
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- Kronberg-Kippilä, Carina (author)
- Finnish National Institute for Health and Welfare
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- Torma, Maija (author)
- Finnish National Institute for Health and Welfare
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- Simell, Barbara (author)
- Finnish National Institute for Health and Welfare
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- Ruohonen, Eeva (author)
- Finnish National Institute for Health and Welfare
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- Romo, Minna (author)
- Finnish National Institute for Health and Welfare
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- Mantymaki, Elina (author)
- Finnish National Institute for Health and Welfare
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- Schroderus, Heidi (author)
- Finnish National Institute for Health and Welfare
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- Nyblom, Mia (author)
- Finnish National Institute for Health and Welfare
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- Stenius, Aino (author)
- Finnish National Institute for Health and Welfare
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Agardh, Daniel (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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Andersson, Eva (author)
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- Andrén-Aronsson, Carin (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ask, Maria (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Karlsson, Ulla Marie (author)
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- Cilio, Corrado (author)
- Lund University,Lunds universitet,Diabetes - immunovirologi,Forskargrupper vid Lunds universitet,Diabetes - Immunovirology,Lund University Research Groups
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- Bremer, Jenny (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Ericson-Hallström, Emilie (author)
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- Gard, Thomas (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Gerardsson, Joanna (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Gustavsson, Ulrika (author)
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- Hansson, Gertie (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Hansen, Monica (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Hyberg, Susanne (author)
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- Håkansson, Rasmus (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ivarsson, Sten (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Johansen, Fredrik (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Larsson, Helena (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups
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- Lernmark, Barbro (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Markan, Maria (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Massadakis, Theodosia (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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Melin, Jessica (author)
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- Månsson-Martinez, Maria (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Nilsson, Anita (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Nilsson, Emma (author)
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- Rahmati, Kobra (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Rang, Sara (author)
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- Järvirova, Monica Sedig (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Sibthorpe, Sara (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Sjöberg, Birgitta (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Törn, Carina (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Wallin, Anne (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Wimar, Åsa (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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Hagopian, William A. (author)
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Yan, Xiang (author)
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Killian, Michael (author)
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Crouch, Claire Cowen (author)
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Hay, Kristen M. (author)
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Ayres, Stephen (author)
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Adams, Carissa (author)
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Bratrude, Brandi (author)
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Fowler, Greer (author)
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Franco, Czarina (author)
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Hammar, Carla (author)
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Heaney, Diana (author)
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Marcus, Patrick (author)
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Meyer, Arlene (author)
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Mulenga, Denise (author)
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Scott, Elizabeth (author)
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Skidmore, Jennifer (author)
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Small, Erin (author)
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Stabbert, Joshua (author)
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Stepitova, Viktoria (author)
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Becker, Dorothy (author)
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Franciscus, Margaret (author)
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Dalmagro-Elias Smith, Maryellen (author)
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Daftary, Ashi (author)
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Krischer, Jeffrey P. (author)
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Abbondondolo, Michael (author)
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Ballard, Lori (author)
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Brown, Rasheedah (author)
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Cuthbertson, David (author)
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Eberhard, Christopher (author)
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Gowda, Veena (author)
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Lee, Hye Seung (author)
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Liu, Shu (author)
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Malloy, Jamie (author)
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McCarthy, Cristina (author)
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McLeod, Wendy (author)
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Smith, Laura (author)
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Smith, Stephen (author)
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Smith, Susan (author)
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Uusitalo, Ulla (author)
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Yang, Jimin (author)
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Akolkar, Beena (author)
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Briese, Thomas (author)
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Erlich, Henry (author)
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Oberste, Steve (author)
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(creator_code:org_t)
- 2016-08-26
- 2016
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Haghighi, Mona
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Johnson, Suzanne ...
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Qian, Xiaoning
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Lynch, Kristian ...
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Vehik, Kendra
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Huang, Shuai
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show more...
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Rewers, Marian
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Barriga, Katheri ...
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Baxter, Judith
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Eisenbarth, Geor ...
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Frank, Nicole
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Gesualdo, Patric ...
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Hoffman, Michell ...
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Norris, Jill
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Ide, Lisa
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Robinson, Jessie
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Waugh, Kathleen
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She, Jin Xiong
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Schatz, Desmond
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Hopkins, Diane
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Steed, Leigh
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Choate, Angela
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Silvis, Katherin ...
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Shankar, Meena
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Huang, Yi Hua
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Yang, Ping
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Wang, Hong Jie
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Leggett, Jessica
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English, Kim
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McIndoe, Richard
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Dequesada, Angel ...
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Haller, Michael
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Anderson, Stephe ...
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Ziegler, Anette ...
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Boerschmann, Hei ...
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Bonifacio, Ezio
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Bunk, Melanie
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Försch, Johannes
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Henneberger, Lyd ...
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Hummel, Michael
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Hummel, Sandra
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Joslowski, Gesa
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Kersting, Mathil ...
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Knopff, Annette
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Kocher, Nadja
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Koletzko, Sibyll ...
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Krause, Stephani ...
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Lauber, Claudia
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Mollenhauer, Ulr ...
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Peplow, Claudia
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Pflüger, Maren
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Pöhlmann, Daniel ...
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Ramminger, Claud ...
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Rash-Sur, Sargol
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Roth, Roswith
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Schenkel, Julia
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Thümer, Leonore
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Voit, Katja
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Winkler, Christi ...
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Zwilling, Marina
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Simell, Olli G.
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Nanto-Salonen, K ...
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Ilonen, Jorma
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Knip, Mikael
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Veijola, Riitta
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Simell, Tuula
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Hyöty, Heikki
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Virtanen, Suvi M ...
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Kronberg-Kippilä ...
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Torma, Maija
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Simell, Barbara
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Ruohonen, Eeva
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Romo, Minna
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Mantymaki, Elina
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Schroderus, Heid ...
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Nyblom, Mia
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Stenius, Aino
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Lernmark, Åke
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Agardh, Daniel
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Almgren, Peter
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Andersson, Eva
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Andrén-Aronsson, ...
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Ask, Maria
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Karlsson, Ulla M ...
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Cilio, Corrado
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Bremer, Jenny
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Ericson-Hallströ ...
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Gard, Thomas
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Gerardsson, Joan ...
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Gustavsson, Ulri ...
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Hansson, Gertie
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Hansen, Monica
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Hyberg, Susanne
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Håkansson, Rasmu ...
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Ivarsson, Sten
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Johansen, Fredri ...
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Larsson, Helena
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Lernmark, Barbro
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Markan, Maria
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Massadakis, Theo ...
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Melin, Jessica
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Månsson-Martinez ...
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Nilsson, Anita
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Nilsson, Emma
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Rahmati, Kobra
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Rang, Sara
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Järvirova, Monic ...
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Sibthorpe, Sara
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Sjöberg, Birgitt ...
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Törn, Carina
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Wallin, Anne
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Wimar, Åsa
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Hagopian, Willia ...
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Yan, Xiang
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Killian, Michael
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Crouch, Claire C ...
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Hay, Kristen M.
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Ayres, Stephen
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Adams, Carissa
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Bratrude, Brandi
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Fowler, Greer
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Franco, Czarina
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Hammar, Carla
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Heaney, Diana
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Marcus, Patrick
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Meyer, Arlene
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Mulenga, Denise
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Scott, Elizabeth
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Skidmore, Jennif ...
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Small, Erin
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Stabbert, Joshua
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Stepitova, Vikto ...
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Becker, Dorothy
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Franciscus, Marg ...
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Dalmagro-Elias S ...
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Daftary, Ashi
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Krischer, Jeffre ...
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Abbondondolo, Mi ...
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Ballard, Lori
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Brown, Rasheedah
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Cuthbertson, Dav ...
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Eberhard, Christ ...
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Gowda, Veena
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Lee, Hye Seung
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Liu, Shu
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Malloy, Jamie
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McCarthy, Cristi ...
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McLeod, Wendy
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Smith, Laura
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Smith, Stephen
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Smith, Susan
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Uusitalo, Ulla
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Yang, Jimin
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Akolkar, Beena
-
Briese, Thomas
-
Erlich, Henry
-
Oberste, Steve
-
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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Scientific Repor ...
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Lund University