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Minimal relapse ris...
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Jakobsen, Lasse H.Aalborg University Hospital,Aalborg University,Aalborg Univ Hosp, Dept Hematol, Sdr Skovvej 15, DK-9000 Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.,Oslo Univ Hosp, Dept Oncol, Oslo, Norway.;Oslo Univ Hosp, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway.
(författare)
Minimal relapse risk and early normalization of survival for patients with Burkitt lymphoma treated with intensive immunochemotherapy : an international study of 264 real-world patients
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-02-04
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Wiley,2020
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11 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:a30ecf36-197d-4ab3-8d1e-d99d36565fd7
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https://lup.lub.lu.se/record/a30ecf36-197d-4ab3-8d1e-d99d36565fd7URI
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https://doi.org/10.1111/bjh.16425DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425116URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-163706URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:142864023URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Funding Agencies|US National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; Danish Cancer SocietyDanish Cancer Society; Danish North Jutland Region
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Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunochemotherapy, retrospective clinic-based and population-based lymphoma registries from six countries were used to identify 264 real-world patients. The median age was 47 years and the majority had advanced-stage disease and elevated LDH. Treatment protocols were R-CODOX-M/IVAC (47%), R-hyper-CVAD (16%), DA-EPOCH-R (11%), R-BFM/GMALL (25%) and other (2%) leading to an overall response rate of 89%. The two-year overall survival and event-free survival were 84% and 80% respectively. For patients in complete remission/unconfirmed, the two-year relapse risk was 6% but diminished to 0·6% for patients reaching 12 months of post-remission event-free survival (pEFS12). The loss of lifetime for pEFS12 patients was 0·4 (95% CI: −0·7 to 2) months. In conclusion, real-world outcomes of adult BL are excellent following intensive immunochemotherapy. For pEFS12 patients, the relapse risk was low and life expectancy similar to that of a general population, which is important information for developing meaningful follow-up strategies with increased focus on survivorship and less focus on routine disease surveillance.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ellin, FredrikLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci Lund, Oncol, Lund, Sweden.(Swepub:lu)med-fke
(författare)
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Smeland, Knut B.Oslo university hospital,Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
(författare)
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Wästerlid, ToveKarolinska Institutet(Swepub:lu)med-twl
(författare)
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Christensen, Jacob H.Odense University Hospital,Odense Univ Hosp, Dept Hematol, Odense, Denmark.
(författare)
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Jørgensen, Judit M.Aarhus University Hospital,Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark.,Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
(författare)
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Josefsson, Pär L.Herlev Hospital,Herlev Hosp, Dept Hematol, Herlev, Denmark.
(författare)
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Øvlisen, Andreas K.Aalborg University Hospital,Aalborg University,Aalborg Univ Hosp, Dept Hematol, Sdr Skovvej 15, DK-9000 Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
(författare)
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Holte, HaraldOslo university hospital,Roskilde Sygehus, Dept Hematol, Roskilde, Denmark.
(författare)
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Blaker, Yngvild N.Oslo university hospital,Oslo Univ Hosp, KG Jebsen Ctr B Cell Malignancies, Oslo, Norway.;Oslo Univ Hosp, Inst Canc Res, Dept Canc Immunol, Oslo, Norway.
(författare)
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Grauslund, Jacob H.Zealand University Hospital
(författare)
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Bjørn, JonCopenhagen University Hospital,Rigshosp, Dept Hematol, Copenhagen, Denmark.
(författare)
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Molin, Daniel,1969-Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi,Uppsala Univ, Sweden(Swepub:uu)danimoli
(författare)
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Lagerlöf, IngemarLinköpings universitet,Linköping University,Linköping Univ, Dept Med & Hlth Sci, Div Drug Res, Linköping, Sweden.,Avdelningen för läkemedelsforskning,Medicinska fakulteten(Swepub:liu)n/a
(författare)
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Smedby, Karin E.Karolinska Institutet
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Colvin, KatherineSir Charles Gairdner Hospital,Sir Charles Gairdner Hosp, Dept Haematol, Nedlands, WA, Australia.
(författare)
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Thanarajasingam, GitaMayo Clinic Minnesota,Mayo Clin, Div Hematol, Rochester, MN USA.
(författare)
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Maurer, Matthew J.Mayo Clinic Minnesota
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Habermann, Thomas M.Mayo Clinic Minnesota,Mayo Clin, Div Hematol, Rochester, MN USA.
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Song, Kevin W.BC Canc, Ctr Lymphoid Canc, Leukemia BMT Program BC, Vancouver, BC, Canada.
(författare)
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Zhu, Katie Y.BC Canc, Ctr Lymphoid Canc, Leukemia BMT Program BC, Vancouver, BC, Canada.
(författare)
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Gerrie, Alina S.BC Canc, Ctr Lymphoid Canc, Leukemia BMT Program BC, Vancouver, BC, Canada.
(författare)
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Cheah, Chan Y.University of Western Australia, Crawley,Sir Charles Gairdner Hospital,Sir Charles Gairdner Hosp, Dept Hematol, Nedlands, WA, Australia.;Pathwest Lab Med WA, Dept Hematol, Nedlands, WA, Australia.;Univ Western Australia, Med Sch, Crawley, Australia.
(författare)
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El-Galaly, Tarec C.Aalborg University,Aalborg University Hospital,Aalborg Univ Hosp, Dept Hematol, Sdr Skovvej 15, DK-9000 Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
(författare)
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Aalborg University HospitalAalborg University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Haematology: Wiley189:4, s. 661-6710007-10481365-2141
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Jakobsen, Lasse ...
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Ellin, Fredrik
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Smeland, Knut B.
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Wästerlid, Tove
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Christensen, Jac ...
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Jørgensen, Judit ...
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visa fler...
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Josefsson, Pär L ...
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Øvlisen, Andreas ...
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Holte, Harald
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Blaker, Yngvild ...
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Grauslund, Jacob ...
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Bjørn, Jon
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Molin, Daniel, 1 ...
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Lagerlöf, Ingema ...
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Smedby, Karin E.
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Colvin, Katherin ...
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Thanarajasingam, ...
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Maurer, Matthew ...
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Habermann, Thoma ...
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Song, Kevin W.
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Zhu, Katie Y.
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Gerrie, Alina S.
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Cheah, Chan Y.
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El-Galaly, Tarec ...
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