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Telomere length is ...
Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
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- Törn, Carina (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Liu, Xiang (author)
- University of South Florida
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- Onengut-Gumuscu, Suna (author)
- University of Virginia Health System
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- Counts, Kevin M (author)
- University of South Florida
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- Moreno, Jose Leonardo (author)
- University of South Florida
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Remedios, Cassandra L (author)
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- Chen, Wei-Min (author)
- University of Virginia Health System
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- LeFaive, Jonathon (author)
- Central Michigan University
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Butterworth, Martha D (author)
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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Krischer, Jeffrey P (author)
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Rewers, Marian (author)
- University of Northern Colorado
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- She, Jin-Xiong (author)
- Medical College of Georgia
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- Toppari, Jorma (author)
- Turku University Hospital
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- Ziegler, Anette-Gabriele (author)
- Helmholtz Zentrum München
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- Ratan, Aakrosh (author)
- University of Virginia Health System
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Smith, Albert V (author)
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- Hagopian, William A (author)
- Pacific Northwest Research Institute
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- Rich, Stephen S (author)
- University of Virginia Health System
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- Parikh, Hemang M (author)
- University of South Florida
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(creator_code:org_t)
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- 2022-03-16
- 2022
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1, s. 4516-4516
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and Motif_counter. The estimated median telomere length was 5.10 kb (IQR 4.52-5.68 kb) using Computel. The age when the blood sample was drawn had a significant negative correlation with telomere length (P = 0.003). European children, particularly those from Finland (P = 0.041) and from Sweden (P = 0.001), had shorter telomeres than children from the U.S.A. Paternal age (P = 0.019) was positively associated with telomere length. First-degree relative status, presence of gestational diabetes in the mother, and maternal age did not have a significant impact on estimated telomere length. HLA-DR4/4 or HLA-DR4/X children had significantly longer telomeres compared to children with HLA-DR3/3 or HLA-DR3/9 haplogenotypes (P = 0.008). Estimated telomere length was not significantly different with respect to any IA (P = 0.377), IAA-first (P = 0.248), GADA-first (P = 0.248) or T1D (P = 0.861). These results suggest that telomere length has no major impact on the risk for IA, the first step to develop T1D. Nevertheless, telomere length was shorter in the T1D high prevalence populations, Finland and Sweden.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- By the author/editor
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Törn, Carina
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Liu, Xiang
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Onengut-Gumuscu, ...
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Counts, Kevin M
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Moreno, Jose Leo ...
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Remedios, Cassan ...
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show more...
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Chen, Wei-Min
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LeFaive, Jonatho ...
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Butterworth, Mar ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Lernmark, Åke
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Rewers, Marian
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She, Jin-Xiong
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Toppari, Jorma
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Ziegler, Anette- ...
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Ratan, Aakrosh
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Smith, Albert V
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Hagopian, Willia ...
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Rich, Stephen S
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Parikh, Hemang M
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Lund University