High pro‑neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow‑up

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Cimini Flavia Agata) > High pro‑neurotensi...

Cimini, Flavia AgataSapienza University of Rome (författare)

High pro‑neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow‑up

Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

2021-08-29
Springer Science and Business Media LLC,2022

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:a33a17a1-568f-4b4f-848a-ed0986d721c1
https://lup.lub.lu.se/record/a33a17a1-568f-4b4f-848a-ed0986d721c1URI
https://doi.org/10.1007/s00592-021-01783-xDOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

Aims: Neurotensin (NT) is a gut hormone that promotes lipids absorption and controls appetite. Elevated circulating pro-NT, the stable precursor of NT, is associated with cardiovascular (CV) disease, metabolic syndrome (MS) and type 2 diabetes (T2D). Features of MS and insulin resistance are reported also in type 1 diabetes (T1D), with detrimental impact on the overall CV risk profile. Aims of the study were to evaluate plasma pro-NT in T1D patients and to test whether its levels are associated with and/or predictive of CV risk factors and overall risk profile.Methods: For this longitudinal retrospective study, we analyzed clinical data from 41 T1D individuals referring to the diabetes outpatient clinics at Sapienza University of Rome, Italy, collected at the baseline and after 10 years. Fasting plasma pro-NT levels were measured in T1D subjects at the baseline and in 34 age-, sex-, BMI-comparable healthy individuals recruited in the same period.Results: Pro-NT did not differ significantly between patients and controls (median[range] pro-NT: 156.3 [96.6-198.2] vs. 179.4 [139.7-230.7] pmol/L, p = 0.26). In T1D, greater fasting pro-NT associated with poor glycemic control at baseline and predicted increased waist circumference, reduced insulin sensitivity, dyslipidemia and hypertension at 10-year follow-up. High pro-NT predicted 10-year very-high CV risk with adjusted OR = 11 (95%C.I.: 1.4-94.5; p = 0.029).Conclusions: In T1D individuals, elevated pro-NT levels predict the development of adverse metabolic profile, which translates in higher CV risk profile at 10-year follow-up. Pro-NT represents a novel predictor/marker of CV risk factors in adults with T1D.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Biomarkers
Cardiovascular disease
Gastrointestinal peptides
Neuropeptides
Neurotensin
Type 1 Diabetes

Biuppslag (personer, institutioner, konferenser, titlar ...)

Barchetta, IlariaSapienza University of Rome(Swepub:lu)med-iib (författare)
Bertoccini, LauraSapienza University of Rome (författare)
Ceccarelli, ValentinaSapienza University of Rome (författare)
Baroni, Marco GiorgioUniversity of L'Aquila (författare)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome (författare)
Cavallo, Maria GisellaSapienza University of Rome (författare)
Sapienza University of RomeUniversity of L'Aquila (creator_code:org_t)

Sammanhörande titlar

Ingår i:Acta Diabetologica: Springer Science and Business Media LLC59:1, s. 49-560940-54291432-5233

Internetlänk

Hitta via bibliotek

Acta Diabetologica (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Cimini, Flavia A ...; Barchetta, Ilari ...; Bertoccini, Laur ...; Ceccarelli, Vale ...; Baroni, Marco Gi ...; Melander, Olle; visa fler...; Cavallo, Maria G ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

Artiklar i publikationen: Acta Diabetologi ...

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se