Patients with a fast progression profile in geographic atrophy have increased CD200 expression on circulating monocytes

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Krogh Nielsen, MarieUniversity of Copenhagen,Zealand University Hospital (författare)

Patients with a fast progression profile in geographic atrophy have increased CD200 expression on circulating monocytes

Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

2018-08-21
Wiley,2019

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:a3955cc6-c23c-4e2a-aff6-83ac78909427
https://lup.lub.lu.se/record/a3955cc6-c23c-4e2a-aff6-83ac78909427URI
https://doi.org/10.1111/ceo.13362DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

Importance: Geographic atrophy (GA) is a progressing atrophy of the neuroretina with no treatment option. Background: Age-related malfunction of retinal microglia amplifies response towards age-related tissue stress in age-related macular degeneration. Here, we investigated monocyte CD200 expression – the circulating middleman negotiating retinal microglial activity – in a poorly understood subtype of age-related macular degeneration. Design: Prospective case–control study. Participants: Forty-six patients with GA and 26 healthy controls were included. Methods: All participants were subjected to a structured interview and detailed retinal examination. Controls were recruited from patient's spouses accompanying them in the clinic to match the groups best possibly. Participants had no history of immune disorders or cancer, and did not receive any immune-modulating medication. Patients did not have any history or sign of choroidal neovascularization in either eye. Fresh drawn blood was stained with monoclonal antibodies and prepared for flow cytometry to evaluate CD200 expression in monocytes and their functional subsets. Main Outcome Measures: The percentage of CD200+ monocytes in patients and controls. Results: We found that monocytes were more CD200 positive in patients with GA compared to healthy age-matched controls. Then, we explored the potential relationship between CD200 expression and important fundus autofluorescence patterns that predict disease progression. Patients with a high risk of progression (patients with high degree of hyperautofluorescence) had distinctly increased CD200 expression compared to other patients with GA. Conclusions and Relevance: Our data reveals that abnormal monocytic CD200 expression is present in GA, and in particular among those identified as fast progressors.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oftalmologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Ophthalmology hsv//eng
age-related macular degeneration
CD200 membrane glycoprotein
geographic atrophy
microglia
monocytes

Biuppslag (personer, institutioner, konferenser, titlar ...)

Subhi, YousifZealand University Hospital,University of Copenhagen (författare)
Molbech, Christopher R.Zealand University Hospital,University of Copenhagen (författare)
Falk, Mads K.Zealand University Hospital (författare)
Singh, AmardeepLund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Zealand University Hospital(Swepub:lu)am1005si (författare)
Nissen, Mogens H.University of Copenhagen (författare)
Sørensen, Torben L.Zealand University Hospital,University of Copenhagen (författare)
University of CopenhagenZealand University Hospital (creator_code:org_t)

Sammanhörande titlar

Ingår i:Clinical and Experimental Ophthalmology: Wiley47:1, s. 69-781442-6404

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Clinical and Experimental Ophthalmology (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Krogh Nielsen, M ...; Subhi, Yousif; Molbech, Christo ...; Falk, Mads K.; Singh, Amardeep; Nissen, Mogens H ...; visa fler...; Sørensen, Torben ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Oftalmologi

Artiklar i publikationen: Clinical and Exp ...

Av lärosätet: Lunds universitet

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