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WFRF:(Sjölund Kristina)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005219naa a2200421 4500
001oai:lup.lub.lu.se:a3d70ec7-6d63-4ce4-b4c4-8f4c2b643cd8
003SwePub
008160404s2011 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/18324392 URI
0247 a https://doi.org/10.1016/j.ajpath.2010.10.0262 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lindgren, Davidu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-dli
2451 0a Isolation and characterization of progenitor-like cells from human renal proximal tubules.
264 1b Elsevier BV,c 2011
520 a The tubules of the kidney display a remarkable capacity for self-renewal on damage. Whether this regeneration is mediated by dedifferentiating surviving cells or, as recently suggested, by stem cells has not been unequivocally settled. Herein, we demonstrate that aldehyde dehydrogenase (ALDH) activity may be used for isolation of cells with progenitor characteristics from adult human renal cortical tissue. Gene expression profiling of the isolated ALDH(high) and ALDH(low) cell fractions followed by immunohistochemical interrogation of renal tissues enabled us to delineate a tentative progenitor cell population scattered through the proximal tubules (PTs). These cells expressed CD24 and CD133, previously described markers for renal progenitors of Bowman's capsule. Furthermore, we show that the PT cells, and the glomerular progenitors, are positive for KRT7, KRT19, BCL2, and vimentin. In addition, tubular epithelium regenerating on acute tubular necrosis displayed long stretches of CD133(+)/VIM(+) cells, further substantiating that these cells may represent a progenitor cell population. Furthermore, a potential association of these progenitor cells with papillary renal cell carcinoma was discovered. Taken together, our data demonstrate the presence of a previously unappreciated subset of the PT cells that may be endowed with a more robust phenotype, allowing increased resistance to acute renal injury, enabling rapid repopulation of the tubules.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Boström, Anna-Karinu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-abm
7001 a Nilsson, Kristinau Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-kn0
7001 a Hansson, Jenniferu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-jih
7001 a Sjölund, Jonasu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-sjo
7001 a Möller, Christinau Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-mlc
7001 a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji
7001 a Nilsson, Eliseu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-eni
7001 a Landberg, Göranu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-gla
7001 a Axelson, Håkanu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-hax
7001 a Johansson, Martinu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-mim
7102 a Institutionen för translationell medicinb Medicinska fakulteten4 org
7730 t American Journal of Pathologyd : Elsevier BVg 178:2, s. 828-837q 178:2<828-837x 1525-2191x 0002-9440
8564 u http://www.ncbi.nlm.nih.gov/pubmed/21281815?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1016/j.ajpath.2010.10.026y FULLTEXT
8564 u http://ajp.amjpathol.org/article/S0002944010001197/pdf
8564 8u https://lup.lub.lu.se/record/1832439
8564 8u https://doi.org/10.1016/j.ajpath.2010.10.026

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