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EAU-EANM Consensus ...
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Fanti, StefanoUniversity of Bologna
(författare)
EAU-EANM Consensus Statements on the Role of Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Patients with Prostate Cancer and with Respect to [177Lu]Lu-PSMA Radioligand Therapy
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:a4db4ef8-263e-401f-900b-eb7da256808c
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https://lup.lub.lu.se/record/a4db4ef8-263e-401f-900b-eb7da256808cURI
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https://doi.org/10.1016/j.euo.2022.05.003DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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BACKGROUND: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is useful for selected clinical indications in patients with prostate cancer (PCa) but it may have broader clinical utility owing to the emergence of lutetium-177-PSMA-617 ([177Lu]Lu-PSMA) therapy. However, robust data regarding the impact of PSMA PET/CT on patient management and treatment are lacking, and in many areas, the role of next-generation imaging has not been defined. OBJECTIVE: To assess expert opinion on the use of PSMA-based imaging and therapy to develop interim guidance. DESIGN, SETTING, AND PARTICIPANTS: A panel of 21 PCa experts from various disciplines received thematic topics and relevant literature. A questionnaire to assess proposed guidance statements regarding PSMA PET/CT and [177Lu]Lu-PSMA therapy was developed for completion remotely in a first e-Delphi round. A subsequent panel discussion was conducted during a 1-d meeting, which included a second Delphi round. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Panellists voted anonymously on statements using a nine-point Likert scale from 1 = strongly disagree to 9 = strongly agree. Median scores were calculated and consensus was assessed using methods proposed by the Research and Development (RAND) corporation. RESULTS AND LIMITATIONS: Statements were developed to cover the following topics: PSMA PET/CT utility, clinical use, and choice of tracer; patient selection; and management of patients receiving [177Lu]Lu-PSMA for metastatic PCa. Consensus was reached for 33/36 statements. In-group bias is a potential limitation, as some statements were rephrased during discussions at the 1-d meeting. CONCLUSIONS: Adoption of PSMA PET/CT as an imaging tool to guide [177Lu]Lu-PSMA therapy should be supported by indications for appropriate use. PATIENT SUMMARY: A panel of experts in prostate cancer reached a consensus for the majority of statements proposed regarding the role of prostate-specific membrane antigen (PSMA)-based imaging and therapy, particularly the use of PSMA-based imaging in patients suitable for [177Lu]Lu-PSMA therapy and the need to perform PSMA-based imaging before considering patients as candidates for this therapy.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Briganti, Alberto
(författare)
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Emmett, LouiseSt Vincent's Hospital, Sydney
(författare)
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Fizazi, Karim
(författare)
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Gillessen, SilkeOncology Institute of Southern Switzerland
(författare)
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Goffin, KarolienUniversity Hospitals Leuven
(författare)
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Hadaschik, Boris A.University of Duisburg-Essen
(författare)
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Herrmann, KenUniversity of Duisburg-Essen
(författare)
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Kunikowska, JolantaMedical University of Warsaw
(författare)
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Maurer, TobiasUniversity Medical Center Hamburg-Eppendorf
(författare)
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MacLennan, StevenUniversity of Aberdeen
(författare)
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Mottet, Nicolas
(författare)
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Murphy, Declan G.University of Melbourne
(författare)
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Oprea-Lager, Daniela E.Academic Medical Center of University of Amsterdam (AMC)
(författare)
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O'Sullivan, Joe M.Queen's University Belfast
(författare)
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Oyen, Wim J.G.Humanitas University
(författare)
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Rouvière, OlivierHôpital Edouard Herriot
(författare)
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Sartor, OliverTulane University School of Medicine
(författare)
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Stenzl, ArnulfUniversity of Tübingen
(författare)
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Van Poppel, HendrikCatholic University of Leuven
(författare)
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Walz, JochenInstitut Paoli-Calmettes
(författare)
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Witjes, Wim
(författare)
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Bjartell, AndersLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)kir-abj
(författare)
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University of BolognaSt Vincent's Hospital, Sydney
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Urology Oncology: Elsevier BV5:5, s. 530-5362588-9311
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Fanti, Stefano
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Briganti, Albert ...
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Emmett, Louise
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Fizazi, Karim
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Gillessen, Silke
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Goffin, Karolien
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visa fler...
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Hadaschik, Boris ...
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Herrmann, Ken
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Kunikowska, Jola ...
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Maurer, Tobias
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MacLennan, Steve ...
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Mottet, Nicolas
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Murphy, Declan G ...
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Oprea-Lager, Dan ...
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O'Sullivan, Joe ...
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Oyen, Wim J.G.
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Rouvière, Olivie ...
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Sartor, Oliver
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Stenzl, Arnulf
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Van Poppel, Hend ...
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Walz, Jochen
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Witjes, Wim
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Bjartell, Anders
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