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Sökning: onr:"swepub:oai:lup.lub.lu.se:a4db4ef8-263e-401f-900b-eb7da256808c" > EAU-EANM Consensus ...

  • Fanti, StefanoUniversity of Bologna (författare)

EAU-EANM Consensus Statements on the Role of Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Patients with Prostate Cancer and with Respect to [177Lu]Lu-PSMA Radioligand Therapy

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2022
  • 7 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:a4db4ef8-263e-401f-900b-eb7da256808c
  • https://lup.lub.lu.se/record/a4db4ef8-263e-401f-900b-eb7da256808cURI
  • https://doi.org/10.1016/j.euo.2022.05.003DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • BACKGROUND: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is useful for selected clinical indications in patients with prostate cancer (PCa) but it may have broader clinical utility owing to the emergence of lutetium-177-PSMA-617 ([177Lu]Lu-PSMA) therapy. However, robust data regarding the impact of PSMA PET/CT on patient management and treatment are lacking, and in many areas, the role of next-generation imaging has not been defined. OBJECTIVE: To assess expert opinion on the use of PSMA-based imaging and therapy to develop interim guidance. DESIGN, SETTING, AND PARTICIPANTS: A panel of 21 PCa experts from various disciplines received thematic topics and relevant literature. A questionnaire to assess proposed guidance statements regarding PSMA PET/CT and [177Lu]Lu-PSMA therapy was developed for completion remotely in a first e-Delphi round. A subsequent panel discussion was conducted during a 1-d meeting, which included a second Delphi round. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Panellists voted anonymously on statements using a nine-point Likert scale from 1 = strongly disagree to 9 = strongly agree. Median scores were calculated and consensus was assessed using methods proposed by the Research and Development (RAND) corporation. RESULTS AND LIMITATIONS: Statements were developed to cover the following topics: PSMA PET/CT utility, clinical use, and choice of tracer; patient selection; and management of patients receiving [177Lu]Lu-PSMA for metastatic PCa. Consensus was reached for 33/36 statements. In-group bias is a potential limitation, as some statements were rephrased during discussions at the 1-d meeting. CONCLUSIONS: Adoption of PSMA PET/CT as an imaging tool to guide [177Lu]Lu-PSMA therapy should be supported by indications for appropriate use. PATIENT SUMMARY: A panel of experts in prostate cancer reached a consensus for the majority of statements proposed regarding the role of prostate-specific membrane antigen (PSMA)-based imaging and therapy, particularly the use of PSMA-based imaging in patients suitable for [177Lu]Lu-PSMA therapy and the need to perform PSMA-based imaging before considering patients as candidates for this therapy.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Briganti, Alberto (författare)
  • Emmett, LouiseSt Vincent's Hospital, Sydney (författare)
  • Fizazi, Karim (författare)
  • Gillessen, SilkeOncology Institute of Southern Switzerland (författare)
  • Goffin, KarolienUniversity Hospitals Leuven (författare)
  • Hadaschik, Boris A.University of Duisburg-Essen (författare)
  • Herrmann, KenUniversity of Duisburg-Essen (författare)
  • Kunikowska, JolantaMedical University of Warsaw (författare)
  • Maurer, TobiasUniversity Medical Center Hamburg-Eppendorf (författare)
  • MacLennan, StevenUniversity of Aberdeen (författare)
  • Mottet, Nicolas (författare)
  • Murphy, Declan G.University of Melbourne (författare)
  • Oprea-Lager, Daniela E.Academic Medical Center of University of Amsterdam (AMC) (författare)
  • O'Sullivan, Joe M.Queen's University Belfast (författare)
  • Oyen, Wim J.G.Humanitas University (författare)
  • Rouvière, OlivierHôpital Edouard Herriot (författare)
  • Sartor, OliverTulane University School of Medicine (författare)
  • Stenzl, ArnulfUniversity of Tübingen (författare)
  • Van Poppel, HendrikCatholic University of Leuven (författare)
  • Walz, JochenInstitut Paoli-Calmettes (författare)
  • Witjes, Wim (författare)
  • Bjartell, AndersLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)kir-abj (författare)
  • University of BolognaSt Vincent's Hospital, Sydney (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Urology Oncology: Elsevier BV5:5, s. 530-5362588-9311

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