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Ventilatory setting...
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients : a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
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- Robba, Chiara (författare)
- Ospedale Policlinico San Martino,University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy
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- Badenes, Rafael (författare)
- University of Valencia,Valencia University Hospital,Hosp Clin Univ Valencia, Spain; Univ Valencia, Spain
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- Lilja, Gisela (författare)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden
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visa fler...
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- Friberg, Hans (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Lund Univ, Sweden
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- Chew, Michelle S. (författare)
- Linköpings universitet,Linköping University,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Unden, Johan (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Halmstad County Hospital,Lund Univ, Sweden; Lund Univ, Sweden
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- Lundin, Andreas (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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- Annborn, Martin (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
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- Dankiewicz, Josef (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Sweden
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- Nielsen, Niklas (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund University Bioimaging Center,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Lund Univ, Sweden
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- Pelosi, Paolo (författare)
- Ospedale Policlinico San Martino,University of Genoa,San Martino Policlin Hosp, Italy; Univ Genoa, Italy
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- Ullén, Susann (författare)
- Skåne University Hospital
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- Cronberg, Tobias (creator_code:cre_t)
- Lund University,Lunds universitet,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Center for cardiac arrest,Lund University Research Groups
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- Erlinge, David (creator_code:cre_t)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups
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- Levin, Helena (creator_code:cre_t)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups
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- Nordberg, Per (creator_code:cre_t)
- Karolinska Institute
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- Palmér, Karolina (creator_code:cre_t)
- Region Skåne
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- Karlsson, Ulla Britt (creator_code:cre_t)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Heissler, Simon (creator_code:cre_t)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ceric, Ameldina (creator_code:cre_t)
- Helsingborg Hospital
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- Haxhija, Zana (creator_code:cre_t)
- Helsingborg Hospital
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- Düring, Joachim (creator_code:cre_t)
- Skåne University Hospital
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- Bergström, Mattias (creator_code:cre_t)
- Skåne University Hospital
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- Didriksson, Ingrid (creator_code:cre_t)
- Skåne University Hospital
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- Frid, Petrea (creator_code:cre_t)
- Skåne University Hospital
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- Heimburg, Katarina (creator_code:cre_t)
- Skåne University Hospital
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- Lundberg, Oscar (creator_code:cre_t)
- Skåne University Hospital
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- Hau, Stefan Olsson (creator_code:cre_t)
- Skåne University Hospital
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- Schmidbauer, Simon (creator_code:cre_t)
- Skåne University Hospital,Univ Libre Bruxelles, Belgium
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- Borgquist, Ola (creator_code:cre_t)
- Skåne University Hospital
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- Bjärnroos, Anna (creator_code:cre_t)
- Skåne University Hospital
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- Blennow Nordström, Erik (creator_code:cre_t)
- Skåne University Hospital
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- Dragancea, Irina (creator_code:cre_t)
- Skåne University Hospital
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- Kander, Thomas (creator_code:cre_t)
- Skåne University Hospital
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- Lybeck, Anna (creator_code:cre_t)
- Skåne University Hospital
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- Mattiasson, Gustav (creator_code:cre_t)
- Region Skåne
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- Persson, Olof (creator_code:cre_t)
- Skåne University Hospital
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- Rundgren, Malin (creator_code:cre_t)
- Skåne University Hospital
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- Westhall, Erik (creator_code:cre_t)
- Skåne University Hospital
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- Andertun, Sara (creator_code:cre_t)
- Helsingborg Hospital
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- Ebner, Florian (creator_code:cre_t)
- Helsingborg Hospital
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- Johnsson, Jesper (creator_code:cre_t)
- Karolinska Institutet
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- Battaglini, Denise (författare)
- San Martino Policlin Hosp, Italy; Univ Barcelona, Spain
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- Ball, Lorenzo (författare)
- San Martino Policlin Hosp, Italy; Univ Genoa, Italy
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- Brunetti, Iole (författare)
- San Martino Policlin Hosp, Italy
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- Jakobsen, Janus C. (författare)
- Copenhagen Univ Hosp, Denmark; Univ Southern Denmark, Denmark
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- Wendel-Garcia, Pedro D. (författare)
- Univ Hosp Zurich, Switzerland
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- Eastwood, Glenn (författare)
- Austin Hosp, Australia
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- Thomas, Matthew (författare)
- Univ Hosp Bristol NHS Fdn Trust, England
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- Joannidis, Michael (författare)
- Med Univ Innsbruck, Austria
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- Nichol, Alistair (författare)
- Monash Univ, Australia
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- Hollenberg, Jacob (författare)
- Karolinska Inst, Sweden
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- Hammond, Naomi (författare)
- UNSW Sydney, Australia
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- Saxena, Manoj (författare)
- St George Hosp, Australia
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- Solar, Miroslav (författare)
- Charles Univ Prague, Czech Republic; Univ Hosp Hradec Kralove, Czech Republic
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(creator_code:org_t)
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- 2022-07-02
- 2022
- Engelska 15 s.
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Ingår i: Intensive Care Medicine. - : Springer Science and Business Media LLC. - 0342-4642 .- 1432-1238. ; 48:8, s. 1024-1038
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Purpose: The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Methods: Preplanned sub-analysis of the Target Temperature Management-2 trial. Clinical outcomes were mortality and functional status (assessed by the Modified Rankin Scale) 6 months after randomization. Results: A total of 1848 patients were included (mean age 64 [Standard Deviation, SD = 14] years). At 6 months, 950 (51%) patients were alive and 898 (49%) were dead. Median tidal volume (VT) was 7 (Interquartile range, IQR = 6.2–8.5) mL per Predicted Body Weight (PBW), positive end expiratory pressure (PEEP) was 7 (IQR = 5–9) cmH20, plateau pressure was 20 cmH20 (IQR = 17–23), driving pressure was 12 cmH20 (IQR = 10–15), mechanical power 16.2 J/min (IQR = 12.1–21.8), ventilatory ratio was 1.27 (IQR = 1.04–1.6), and respiratory rate was 17 breaths/minute (IQR = 14–20). Median partial pressure of oxygen was 87 mmHg (IQR = 75–105), and partial pressure of carbon dioxide was 40.5 mmHg (IQR = 36–45.7). Respiratory rate, driving pressure, and mechanical power were independently associated with 6-month mortality (omnibus p-values for their non-linear trajectories: p < 0.0001, p = 0.026, and p = 0.029, respectively). Respiratory rate and driving pressure were also independently associated with poor neurological outcome (odds ratio, OR = 1.035, 95% confidence interval, CI = 1.003–1.068, p = 0.030, and OR = 1.005, 95% CI = 1.001–1.036, p = 0.048). A composite formula calculated as [(4*driving pressure) + respiratory rate] was independently associated with mortality and poor neurological outcome. Conclusions: Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Cardiac arrest
- Driving pressure
- Mechanical power
- Mechanical ventilation
- Outcome
- Ventilator settings
- Mechanical ventilation; Cardiac arrest; Outcome; Mechanical power; Driving pressure; Ventilator settings
- respiratory-distress-syndrome
- intensive-care units
- therapeutic
- hypothermia
- carbon-dioxide
- lung injury
- metaanalysis
- mortality
- pressure
- management
- oxygen
- General & Internal Medicine
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Robba, Chiara
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Badenes, Rafael
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Lilja, Gisela
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Friberg, Hans
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Chew, Michelle S ...
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Unden, Johan
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visa fler...
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Lundin, Andreas
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Annborn, Martin
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Dankiewicz, Jose ...
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Nielsen, Niklas
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Pelosi, Paolo
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Ullén, Susann
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Cronberg, Tobias
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Erlinge, David
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Levin, Helena
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Nordberg, Per
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Palmér, Karolina
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Karlsson, Ulla B ...
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Heissler, Simon
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Ceric, Ameldina
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Haxhija, Zana
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Düring, Joachim
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Bergström, Matti ...
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Didriksson, Ingr ...
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Frid, Petrea
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Heimburg, Katari ...
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Lundberg, Oscar
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Hau, Stefan Olss ...
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Schmidbauer, Sim ...
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Borgquist, Ola
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Bjärnroos, Anna
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Blennow Nordströ ...
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Dragancea, Irina
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Kander, Thomas
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Lybeck, Anna
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Mattiasson, Gust ...
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Persson, Olof
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Rundgren, Malin
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Westhall, Erik
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Andertun, Sara
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Ebner, Florian
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Johnsson, Jesper
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Battaglini, Deni ...
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Ball, Lorenzo
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Brunetti, Iole
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Jakobsen, Janus ...
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Wendel-Garcia, P ...
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Eastwood, Glenn
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Thomas, Matthew
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Joannidis, Micha ...
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Nichol, Alistair
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Hollenberg, Jaco ...
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Hammond, Naomi
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Saxena, Manoj
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Solar, Miroslav
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Anestesi och int ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Intensive Care M ...
- Av lärosätet
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Lunds universitet
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Linköpings universitet
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Karolinska Institutet
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Göteborgs universitet