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Vaccine-induced, bu...
Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease
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- Tan, Lionel K.K. (author)
- Imperial College London
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- Reglinski, Mark (author)
- Imperial College London,Ninewells Hospital and Medical School
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- Teo, Daryl (author)
- Imperial College London
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- Reza, Nada (author)
- Imperial College London
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- Lamb, Lucy E.M. (author)
- Imperial College London,New Queen Elizabeth Hospital
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- Nageshwaran, Vaitehi (author)
- Imperial College London
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- Turner, Claire E. (author)
- Imperial College London,University of Sheffield
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- Wikstrom, Mats (author)
- Amgen Inc.,University of Copenhagen
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- Frick, Inga Maria (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Bjorck, Lars (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Sriskandan, Shiranee (author)
- Imperial College London
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(creator_code:org_t)
- 2021-04-22
- 2021
- English.
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In: npj Vaccines. - : Springer Science and Business Media LLC. - 2059-0105. ; 6
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Abstract
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- Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective against invasive S. pyogenes infection. Immunisation with full-length SIC protected mice against systemic bacterial dissemination following intranasal or intramuscular infection with emm1 S. pyogenes. Vaccine-induced rabbit anti-SIC antibodies, but not naturally occurring human anti-SIC antibodies, enhanced bacterial clearance in an ex vivo whole-blood assay. SIC vaccination of both mice and rabbits resulted in antibody recognition of all domains of SIC, whereas naturally occurring human anti-SIC antibodies recognised the proline-rich region of SIC only. We, therefore, propose a model whereby natural infection with S. pyogenes generates non-protective antibodies against the proline-rich region of SIC, while vaccination with full-length SIC permits the development of protective antibodies against all SIC domains.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tan, Lionel K.K.
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Reglinski, Mark
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Teo, Daryl
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Reza, Nada
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Lamb, Lucy E.M.
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Nageshwaran, Vai ...
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show more...
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Turner, Claire E ...
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Wikstrom, Mats
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Frick, Inga Mari ...
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Bjorck, Lars
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Sriskandan, Shir ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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npj Vaccines
- By the university
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Lund University