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Cystatin C, a human...
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Björck, LarsLund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine
(författare)
Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus
- Artikel/kapitelEngelska1990
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LIBRIS-ID:oai:lup.lub.lu.se:a529f66f-596d-4cd9-b435-77b605daa6aa
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https://lup.lub.lu.se/record/a529f66f-596d-4cd9-b435-77b605daa6aaURI
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https://doi.org/10.1128/JVI.64.2.941-943.1990DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.
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Grubb, AndersSkåne University Hospital(Swepub:lu)kkem-agr
(författare)
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Kjellén, LarsLund University
(författare)
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Lunds universitetMedicinska fakulteten
(creator_code:org_t)
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Ingår i:Journal of Virology64:2, s. 941-9430022-538X
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