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Coronary flow and r...
Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass in piglets
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- Liuba, Petru (författare)
- Skåne University Hospital
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- Johansson, Sune (författare)
- Skåne University Hospital
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- Pesonen, Erkki (författare)
- Skåne University Hospital
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- Odermarsky, Michal (författare)
- Skåne University Hospital
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- Kornerup-Hansen, Axel (författare)
- University of Copenhagen
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- Forslid, Anders (författare)
- Lund University,Lunds universitet,Universitetsveterinären,Medicinska fakulteten,University Veterinary,Faculty of Medicine
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- Aburawi, Elhadi H. (författare)
- United Arab Emirates University
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- Higgins, Thomas (författare)
- Skåne University Hospital
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- Birck, Malene (författare)
- University of Copenhagen
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- Perez de Sá, Valéria (författare)
- Skåne University Hospital
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(creator_code:org_t)
- 2013-06-19
- 2013
- Engelska.
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Ingår i: Journal of Cardiothoracic Surgery. - : Springer Science and Business Media LLC. - 1749-8090. ; 8
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Abstract
Ämnesord
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- Background: Surgery under cardiopulmonary bypass (CPB) is still associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully understood. Abnormalities in coronary flow and function have been suggested to play an important role. Prior studies suggest protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A before CPB. Methods: Barrier-bred piglets (10-12 kg, n=20) underwent CPB for 45 min, with or without antegrade administration of cardioplegic solution. Prior to CPB, half of the animals in each group received an i.v. infusion of 100 mg/kg cyclosporine A. The left anterior descending coronary flow velocity responses to adenosine, serotonin, and atrial pacing, as well as left ventricular function and postsurgical vulnerability to atrial fibrillation (Afib) were assessed by intracoronary Doppler, epicardial echocardiography, and in vivo electrophysiological study, before and 8 hours after surgery. Plasma C-reactive protein (CRP) and fibrinogen were measured at both time-points. Results: Cyclosporine infusion did not influence any of the studied variables (p>0.4). Coronary peak flow velocity (cPFV) rose significantly after surgery especially in the cardioplegia group (p<0.01 vs. non-cardioplegia group and pre-surgery). cPFV responses to adenosine, but not to serotonin, tended to decrease (p=0.06) after surgery only in cardioplegia group (p=0.06; p=0.8 in non-cardioplegia group vs pre-surgery). Also, cPFV response to atrial pacing was lower in the cardioplegia than in the non-cardioplegia group (p=0.02). Neither vulnerability nor duration of induced Afib after CPB differed between groups (Chi-square p=0.4). Cyclosporine had no significant effect on coronary indexes or arrhythmia vulnerability (p>0.4). There was no difference in systolic myocardial function between groups at any time point. Conclusion: In piglets, CPB with cardioplegia was associated with profound abnormalities in coronary vasomotor tone and receptor-related flow regulation, whereas arrhythmia vulnerability appeared to be comparable with that in non-cardioplegia group. In this study, preconditioning with cyclosporine had no detectable protective effect on coronary circulation or arrhythmia vulnerability after CPB.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Cardiopulmonary bypass
- Coronary
- Cardioplegia
- Piglets
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Liuba, Petru
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Johansson, Sune
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Pesonen, Erkki
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Odermarsky, Mich ...
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Kornerup-Hansen, ...
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Forslid, Anders
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visa fler...
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Aburawi, Elhadi ...
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Higgins, Thomas
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Birck, Malene
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Perez de Sá, Val ...
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