Search: (WFRF:(Michaud K)) srt2:(2010-2014) >
Helicobacter pylori...
Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project
-
Gonzalez, C. A. (author)
-
Megraud, F. (author)
-
Buissonniere, A. (author)
-
show more...
-
Lujan Barroso, L. (author)
-
Agudo, A. (author)
-
Duell, E. J. (author)
-
Boutron-Ruault, M. C. (author)
-
Clavel-Chapelon, F. (author)
-
Palli, D. (author)
-
Krogh, V. (author)
-
Mattiello, A. (author)
-
Tumino, R. (author)
-
Sacerdote, C. (author)
-
Quiros, J. R. (author)
-
Sanchez-Cantalejo, E. (author)
-
Navarro, C. (author)
-
Barricarte, A. (author)
-
Dorronsoro, M. (author)
-
Khaw, K. -T. (author)
-
Wareham, N. (author)
-
Allen, N. E. (author)
-
Tsilidis, K. K. (author)
-
Bueno-de-Mesquita, H. Bas (author)
-
Jeurnink, S. M. (author)
-
Numans, M. E. (author)
-
Peeters, P. H. M. (author)
-
Lagiou, P. (author)
-
Valanou, E. (author)
-
Trichopoulou, A. (author)
-
Kaaks, R. (author)
-
Lukanova-McGregor, A. (author)
-
Bergman, M. M. (author)
-
Boeing, H. (author)
-
- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
-
Lindkvist, B. (author)
-
- Stenling, Roger (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
-
- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
-
Mortensen, L. M. (author)
-
Overvad, K. (author)
-
Olsen, A. (author)
-
Tjonneland, A. (author)
-
Bakken, K. (author)
-
Dumeaux, V. (author)
-
Lund, E. (author)
-
Jenab, M. (author)
-
Romieu, I. (author)
-
Michaud, D. (author)
-
Mouw, T. (author)
-
Carneiro, F. (author)
-
Fenge, C. (author)
-
Riboli, E. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
-
In: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 23:5, s. 1320-1324
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- In epidemiological studies, Helicobacter pylori infection is usually detected by enzyme-linked immunosorbent assay (ELISA). However, infection can spontaneously clear from the mucosa during the progression of atrophy and could lead to substantial under-detection of infection and underestimation of its effect on gastric cancer (GC) risk. Antibodies detected by western blot are known to persist longer after the loss of the infection. In a nested case-control study from the Eurogast-EPIC cohort, including 88 noncardia GC cases and 338 controls, we assessed the association between noncardia GC and H. pylori infection comparing antibodies detected by western blot (HELICOBLOT2.1) to those detected by ELISA (Pyloriset EIA-GIII((R))). By immunoblot, 82 cases (93.2%) were H. pylori positive, 10 of these cases (11.4%) were negative by ELISA and only 6 cases (6.8%) were negative by both ELISA and immunoblot. Multivariable odds ratio (OR) for noncardia GC comparing immunoglobulin G positive versus negative by ELISA was 6.8 [95% confidence interval (CI) 3.0-15.1], and by immunoblot, the OR was 21.4 (95% CI 7.1-64.4). Using a western blot assay, nearly all noncardia GC were classified as H. pylori positive and the OR was more than threefold higher than the OR assessed by ELISA, supporting the hypothesis that H. pylori infection is a necessary condition for noncardia GC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Helicobacter pylori
- noncardia gastric cancer
- prospective study
- western blot
- Helicobacter pylori
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gonzalez, C. A.
-
Megraud, F.
-
Buissonniere, A.
-
Lujan Barroso, L ...
-
Agudo, A.
-
Duell, E. J.
-
show more...
-
Boutron-Ruault, ...
-
Clavel-Chapelon, ...
-
Palli, D.
-
Krogh, V.
-
Mattiello, A.
-
Tumino, R.
-
Sacerdote, C.
-
Quiros, J. R.
-
Sanchez-Cantalej ...
-
Navarro, C.
-
Barricarte, A.
-
Dorronsoro, M.
-
Khaw, K. -T.
-
Wareham, N.
-
Allen, N. E.
-
Tsilidis, K. K.
-
Bueno-de-Mesquit ...
-
Jeurnink, S. M.
-
Numans, M. E.
-
Peeters, P. H. M ...
-
Lagiou, P.
-
Valanou, E.
-
Trichopoulou, A.
-
Kaaks, R.
-
Lukanova-McGrego ...
-
Bergman, M. M.
-
Boeing, H.
-
Manjer, Jonas
-
Lindkvist, B.
-
Stenling, Roger
-
Hallmans, Göran
-
Mortensen, L. M.
-
Overvad, K.
-
Olsen, A.
-
Tjonneland, A.
-
Bakken, K.
-
Dumeaux, V.
-
Lund, E.
-
Jenab, M.
-
Romieu, I.
-
Michaud, D.
-
Mouw, T.
-
Carneiro, F.
-
Fenge, C.
-
Riboli, E.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Annals of Oncolo ...
- By the university
-
Lund University
-
Umeå University