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North European comp...
North European comparison of treatment strategy and survival in older patients with resectable gastric cancer : A EURECCA upper gastrointestinal group analysis
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- Claassen, Y. H.M. (author)
- Leiden University Medical Centre
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- Johansson, J. (author)
- Lund University,Lunds universitet,Upper Gastrointestinal Surgery,Forskargrupper vid Lunds universitet,Lund University Research Groups,Oslo university hospital,University of Oslo,The Danish Clinical Registries (RKKP),Leiden University Medical Centre
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- Hartgrink, H. H. (author)
- Leiden University Medical Centre,Netherlands Comprehensive Cancer Organisation (IKNL),Belgian Cancer Registry,Royal Marsden NHS Foundation Trust
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- de Steur, W. O. (author)
- Leiden University Medical Centre
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- Slingerland, M. (author)
- Leiden University Medical Centre
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- Verhoeven, R. H.A. (author)
- Netherlands Comprehensive Cancer Organisation (IKNL)
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- van Eycken, E. (author)
- Belgian Cancer Registry
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- de Schutter, H. (author)
- Belgian Cancer Registry
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- Johansson, J. (author)
- Lund University,Lunds universitet,Upper Gastrointestinal Surgery,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Rouvelas, I. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Johnson, E. (author)
- Oslo university hospital,University of Oslo
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- Hjortland, G. O. (author)
- Oslo university hospital
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- Jensen, L. S. (author)
- Aarhus University Hospital
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- Larsson, H. J. (author)
- The Danish Clinical Registries (RKKP)
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- Allum, W. H. (author)
- Royal Marsden NHS Foundation Trust
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- Portielje, J. E.A. (author)
- Leiden University Medical Centre
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- Bastiaannet, E. (author)
- Leiden University Medical Centre
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- van de Velde, C. J.H. (author)
- Leiden University Medical Centre
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983. ; 44:12, s. 1982-1989
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: As older gastric cancer patients are often excluded from randomized clinical trials, the most appropriate treatment strategy for these patients remains unclear. The current study aimed to gain more insight in treatment strategies and relative survival of older patients with resectable gastric cancer across Europe. Methods: Population-based cohorts from Belgium, Denmark, The Netherlands, Norway, and Sweden were combined. Patients ≥70 years with resectable gastric cancer (cT1-4a, cN0-2, cM0), diagnosed between 2004 and 2014 were included. Resection rates, administration of chemotherapy (irrespective of surgery), and relative survival within a country according to stage were determined. Results: Overall, 6698 patients were included. The percentage of operated patients was highest in Belgium and lowest in Sweden for both stage II (74% versus 56%) and stage III disease (57% versus 25%). For stage III, chemotherapy administration was highest in Belgium (44%) and lowest in Sweden (2%). Three year relative survival for stage I, II, and III disease in Belgium was 67.8% (95% CI:62.8–72.6), 41.2% (95% CI:37.3–45.2), 17.8% (95% CI:12.5–24.0), compared with 56.7% (95% CI:51.5–61.7), 31.3% (95% CI:27.6–35.2), 8.2% (95% CI:4.4–13.4) in Sweden. There were no significant differences in treatment strategies of patients with stage I disease. Conclusion: Substantial treatment differences are observed across North European countries for patients with stages II and III resectable gastric cancer aged 70 years or older. In the present comparison, treatment strategies with a higher proportion of patients undergoing surgery seemed to be associated with higher survival rates for patients with stages II or III disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- 70 years
- Elderly
- Gastric cancer
- Resectable
- Survival
- Treatment
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Claassen, Y. H.M ...
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Johansson, J.
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Hartgrink, H. H.
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de Steur, W. O.
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Slingerland, M.
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Verhoeven, R. H. ...
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show more...
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van Eycken, E.
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de Schutter, H.
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Rouvelas, I.
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Johnson, E.
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Hjortland, G. O.
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Jensen, L. S.
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Larsson, H. J.
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Allum, W. H.
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Portielje, J. E. ...
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Bastiaannet, E.
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van de Velde, C. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
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European journal ...
- By the university
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Lund University
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Karolinska Institutet