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Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study
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- Conway, Marie C (author)
- University of Ulster
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- McSorley, Emeir M (author)
- University of Ulster
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- Mulhern, Maria S (author)
- University of Ulster
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- Spence, Toni (author)
- University of Ulster
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- Weslowska, Maria (author)
- University of Ulster
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- Strain, J J (author)
- University of Ulster
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- van Wijngaarden, Edwin (author)
- University of Rochester
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- Davidson, Phil W (author)
- University of Rochester
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- Myers, Gary J (author)
- University of Rochester
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- Wahlberg, Karin E (author)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Applied Mass Spectrometry in Environmental Medicine
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- Shamlaye, Conrad F (author)
- Ministry of Health, Seychelles
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- Cobice, Diego F (author)
- University of Ulster
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- Hyland, Barry W (author)
- University of Ulster
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- Pineda, Daniela (author)
- Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Other operations, LTH,Faculty of Engineering, LTH,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Applied Mass Spectrometry in Environmental Medicine
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- Broberg, Karin (author)
- Karolinska Institute,Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Other operations, LTH,Faculty of Engineering, LTH,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Yeates, Alison J (author)
- University of Ulster
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: British Journal of Nutrition. - 1475-2662. ; 126:11, s. 1687-1697
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Optimal maternal long chain polyunsaturated fatty acid (LCPUFA) status is essential for the developing foetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and α-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). There is limited research on the influence of FADS genotype on cord PUFA status. The current study investigated the influence of maternal and child genetic variation in FADS genotype on cord blood PUFA status in a high fish-eating cohort. Cord blood samples (n=1088) collected from the Seychelles Child Development Study (SCDS) Nutrition Cohort 2 (NC2) were analysed for total serum PUFA. Of those with cord PUFA data available, maternal (n=1062) and child (n=916), FADS1 (rs174537, rs174561), FADS2 (rs174575), and FADS1-FADS2 (rs3834458) were determined. Regression analysis determined that maternal minor allele homozygosity was associated with lower cord blood concentrations of docosahexaenoic acid (DHA) and the sum of EPA+DHA. Lower cord blood AA concentrations were observed in children who were minor allele homozygous for rs3834458 (β=0.075; p=0.037). Children who were minor allele carriers for rs174537, rs174561, rs174575 and rs3834458 had a lower cord blood AA:LA ratio (p<0.05 for all). Both maternal and child FADS genotype were associated with cord LCPUFA concentrations, and therefore, the influence of FADS genotype was observed despite the high intake of preformed dietary LCPUFA from fish in this population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- ref (subject category)
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- By the author/editor
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Conway, Marie C
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McSorley, Emeir ...
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Mulhern, Maria S
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Spence, Toni
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Weslowska, Maria
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Strain, J J
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show more...
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van Wijngaarden, ...
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Davidson, Phil W
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Myers, Gary J
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Wahlberg, Karin ...
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Shamlaye, Conrad ...
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Cobice, Diego F
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Hyland, Barry W
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Pineda, Daniela
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Broberg, Karin
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Yeates, Alison J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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British Journal ...
- By the university
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Lund University