Early repolarization in children with unexplained syncope

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I. Fernlund, EvaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnkardiologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Children cardiology,Lund University Research Groups,Skåne University Hospital (författare)

Early repolarization in children with unexplained syncope

Artikel/kapitelEngelska2011

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Elsevier BV,2011

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LIBRIS-ID:oai:lup.lub.lu.se:a712a3fd-86bb-4b54-a3e1-9df811e5e478
https://lup.lub.lu.se/record/a712a3fd-86bb-4b54-a3e1-9df811e5e478URI
https://doi.org/10.1016/j.jelectrocard.2010.12.031DOI

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Språk:engelska
Sammanfattning på:engelska

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Introduction: It has traditionally been believed that early repolarization (ER) is benign. Significant association between ER and sudden cardiac arrest due to idiopathic ventricular fibrillation was recently found in a large cohort of adult survivors of sudden cardiac arrest. In some prior studies, unexplained syncope has been linked to risk of sudden death, but the mechanisms remain speculative.We assessed herein the prevalence of ER in children referred to our center for unexplained syncope. Methods: We evaluated retrospectively electrocardiograms from such children (n = 29; mean age, 12.1 years; range, 7-18 years) for presence of ER, which was defined as an elevation of the QRS-ST junction (J-point) in at least 2 leads of at least 1 mm (0.1 mV) above the baseline level. The anterior precordial leads (V1-V3) were excluded from the analysis to avoid inclusion of patients with right ventricular dysplasia or Brugada syndrome. Agematched children (n = 33; mean age, 12.3 years; range, 7-16 years) with noncardiac chest pain were included as controls. Results: Early repolarization was detected in 45% (13/29) of children with unexplained syncope vs 24% (8/33) in the chest pain group. Among children with syncope, ER was far more frequent in males than in females (8/12 vs 5/ 17, respectively). Echocardiography showed normal functional and structural findings in all children. Conclusion: In this relatively small-scale retrospective study of children with unexplained syncope with otherwise normal cardiac findings, we found particularly among those of male gender a greater prevalence of ER than in controls (noncardiac chest pain).With view to earlier findings of Haisaguerre et al (NEJM 2008), this intriguing association warrants further prospective studies addressing its precise clinical implication and underlying mechanisms.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
child
faintness
repolarization
acute leukemia
male
prevalence
noncardiac chest pain
heart arrest
adult
survivor
risk
sudden death
electrocardiogram
patient
Brugada syndrome
thorax pain
female
echocardiography
retrospective study
gender
prospective study
heart ventricle fibrillation
heart right ventricle dysplasia

Biuppslag (personer, institutioner, konferenser, titlar ...)

Liuba, PetruLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Barnkardiologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Children cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-pli (författare)
Pediatrik, LundSektion V (creator_code:org_t)

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Ingår i:Journal of Electrocardiology: Elsevier BV44:2, s. 10-101532-84300022-0736

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Av författaren/redakt...: I. Fernlund, Eva; Liuba, Petru

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

Artiklar i publikationen: Journal of Elect ...

Av lärosätet: Lunds universitet

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