(hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin)) pers:(Ahrén Bo)
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- Chan, Hui Min (author)
Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- American Physiological Society,2011
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- LIBRIS-ID:oai:lup.lub.lu.se:a72fe7a2-1a9d-4d12-a154-28eff3a5d9b9
- https://lup.lub.lu.se/record/1988169URI
- https://doi.org/10.1152/ajpregu.00687.2010DOI
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- Language:English
- Summary in:English
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- Chan HM, Jain R, Ahren B, Pacini G, D'Argenio DZ. Effects of increasing doses of glucagon-like peptide-1 on insulin-releasing phases during intravenous glucose administration in mice. Am J Physiol Regul Integr Comp Physiol 300: R1126-R1133, 2011. First published February 9, 2010; doi:10.1152/ajpregu.00687.2010.-The increase in insulin secretion caused by glucagon-like peptide-1 (GLP-1) and GLP-1 mimetics observed during an intravenous glucose test (IVGTT) has been reported in both normal and disease animal models, as well as in humans. In this study, a hierarchical population modeling approach is used, together with a previously reported model relating glucose to insulin appearance, to determine quantitative in vivo dose-response relationships between GLP-1 dose level and both first-and second-phase insulin release. Parameters of the insulin kinetic model were estimated from the complete set of glucose and insulin data collected in 219 anesthetized nonfasted NMR-imaged mice after intravenous injection of glucose (1 g/kg) alone or with GLP-1 (0.03-100 nmol/kg). The resulting dose-response curves indicate a difference in GLP-1 effect on the two release phases, as is also evident from the different ED50 parameter values (0.107 vs. 6.65 nmol/kg for phase 1 vs. phase 2 insulin release parameters). The first phase of insulin release is gradually augmented with increasing GLP-1 dose, reaching saturation at a dose of similar to 1 nmol/kg, while the second-phase release changes more abruptly at GLP-1 doses between 3 and 10 nmol/kg and shows a more pronounced 100-fold increase between control and the high GLP-1 dose of 100 nmol/kg Moreover, separate disposition indices calculated for phase 1 and 2 insulin release, show a different pattern of increase with increasing GLP-1 dose.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
- glucose tolerance
- insulin secretion
- insulin sensitivity
- intravenous
- glucose test
- population analysis
Added entries (persons, corporate bodies, meetings, titles ...)
- Jain, Ritesh (author)
- Ahrén, BoLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bah (author)
- Pacini, Giovanni (author)
- D'Argenio, David Z. (author)
- Medicin, LundSektion II (creator_code:org_t)
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- In:American Journal of Physiology: Regulatory, Integrative and Comparative Physiology: American Physiological Society300:5, s. 1126-11330363-61191522-1490
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