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Incidence of Pediat...
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Stahl, MarisaUniversity of Colorado School of Medicine
(author)
Incidence of Pediatric Celiac Disease Varies by Region
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2022-10-11
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Ovid Technologies (Wolters Kluwer Health),2023
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7 s.
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LIBRIS-ID:oai:lup.lub.lu.se:a75afc12-4a5e-4612-b47a-64e048bb8554
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https://lup.lub.lu.se/record/a75afc12-4a5e-4612-b47a-64e048bb8554URI
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https://doi.org/10.14309/ajg.0000000000002056DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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INTRODUCTION:The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and the United States. Our aim was to identify regional differences in CD autoimmunity and CD cumulative incidence for children born between 2004 and 2010.METHODS:Children (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively from birth in Georgia, Washington, Colorado, Finland, Germany, and Sweden. Children underwent periodic study screening for tissue transglutaminase antibodies and then CD evaluation per clinical care. Population-specific estimates were calculated by weighting the study-specific cumulative incidence with the population-specific haplogenotype frequencies obtained from large stem cell registries from each site.RESULTS:Individual haplogenotype risks for CD autoimmunity and CD varied by region and affected the cumulative incidence within that region. The CD incidence by age 10 years was highest in Swedish children at 3%. Within the United States, the incidence by age 10 years in Colorado was 2.4%. In the model adjusted for HLA, sex, and family history, Colorado children had a 2.5-fold higher risk of CD compared to Washington. Likewise, Swedish children had a 1.4-fold and 1.8-fold higher risk of CD compared with those in Finland and Germany, respectively.DISCUSSION:There is high regional variability in cumulative incidence of CD, which suggests differential environmental, genetic, and epigenetic influences even within the United States. The overall high incidence warrants a low threshold for screening and further research on region-specific CD triggers.
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Li, QianSt Jude Children´s Research Hospital, Memphis
(author)
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Lynch, KristianUniversity of South Florida
(author)
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Koletzko, SibylleUniversity of Warmia and Mazury,University Hospital Munich
(author)
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Mehta, PoojaUniversity of Colorado School of Medicine
(author)
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Gragert, LorenTulane University School of Medicine
(author)
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Norris, Jill M.Colorado School of Public Health
(author)
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Andrén Aronsson, CarinLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)smi-can
(author)
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Lindfors, KatriUniversity of Tampere
(author)
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Kurppa, KalleUniversity of Tampere
(author)
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Ilonen, JormaUniversity of Turku
(author)
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Krischer, JeffreyUniversity of South Florida
(author)
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Alkolkar, BeenaTurku University Hospital,National Institute of Diabetes and Digestive and Kidney Diseases
(author)
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Ziegler, Anette G.Helmholtz Zentrum München
(author)
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Toppari, JormaUniversity of Turku
(author)
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Rewers, Marian J.Barbara Davis Center for Childhood Diabetes
(author)
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Agardh, DanielLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)med-dia
(author)
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Hagopian, WilliamPacific Northwest Research Institute
(author)
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Liu, EdwinUniversity of Colorado School of Medicine
(author)
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University of Colorado School of MedicineSt Jude Children´s Research Hospital, Memphis
(creator_code:org_t)
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TEDDY Study Group
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In:American Journal of Gastroenterology: Ovid Technologies (Wolters Kluwer Health)118:3, s. 539-5450002-92701572-0241
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Stahl, Marisa
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Li, Qian
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Lynch, Kristian
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Koletzko, Sibyll ...
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Mehta, Pooja
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Gragert, Loren
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Norris, Jill M.
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Andrén Aronsson, ...
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Lindfors, Katri
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Kurppa, Kalle
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Ilonen, Jorma
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Krischer, Jeffre ...
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Alkolkar, Beena
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Ziegler, Anette ...
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Toppari, Jorma
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Rewers, Marian J ...
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Agardh, Daniel
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Hagopian, Willia ...
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Liu, Edwin
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