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Quantitative flow r...
Quantitative flow ratio for immediate assessment of nonculprit lesions in patients with ST-segment elevation myocardial infarction—An iSTEMI substudy
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- Sejr-Hansen, Martin (author)
- Aarhus University Hospital
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- Westra, Jelmer (author)
- Aarhus University Hospital
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- Thim, Troels (author)
- Aarhus University Hospital
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- Christiansen, Evald Høj (author)
- Aarhus University Hospital
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- Eftekhari, Ashkan (author)
- Aarhus University Hospital
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- Kristensen, Steen Dalby (author)
- Aarhus University Hospital
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- Jakobsen, Lars (author)
- Aarhus University Hospital
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- Götberg, Matthias (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Frøbert, Ole (author)
- Örebro University Hospital
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- van der Hoeven, Nina W. (author)
- Vrije Universiteit Amsterdam
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- Holm, Niels Ramsing (author)
- Aarhus University Hospital
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- Maeng, Michael (author)
- Aarhus University Hospital
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(creator_code:org_t)
- 2019-03-25
- 2019
- English.
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In: Catheterization and Cardiovascular Interventions. - : Wiley. - 1522-1946 .- 1522-726X. ; 94:5, s. 686-692
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- Objectives: We evaluated the diagnostic performance of quantitative flow ratio (QFR) assessment of nonculprit lesions (NCLs) based on acute setting angiograms obtained in patients with ST-segment elevation myocardial infarction (STEMI) with QFR, fractional flow reserve (FFR), and instantaneous wave-free ratio (iFR) in the staged setting as reference. Background: QFR is an angiography-based approach for the functional evaluation of coronary artery lesions. Methods: This was a post-hoc analysis of the iSTEMI study. NCLs were assessed with iFR in the acute setting and with iFR and FFR at staged (median 13 days) follow-up. Acute and staged QFR values were computed in a core laboratory based on the coronary angiography recordings. Diagnostic cut-off values were ≤0.80 for QFR and FFR, and ≤0.89 for iFR. Results: Staged iFR and FFR data were available for 146 NCLs in 112 patients in the iSTEMI study. Among these, QFR analysis was feasible in 103 (71%) lesions assessed in the acute setting with a mean QFR value of 0.82 (IQR: 0.73–0.91). Staged QFR, FFR, and iFR were 0.80 (IQR: 0.70–0.90), 0.81 (IQR: 0.71–0.88), and 0.91 (IQR: 0.87–0.96), respectively. Classification agreement of acute and staged QFR was 93% (95%Cl: 87–99). The classification agreement of acute QFR was 84% (95%CI: 76–90) using staged FFR as reference and 74% (95%CI: 65–83) using staged iFR as reference. Conclusions: Acute QFR showed a very good diagnostic performance with staged QFR as reference, a good diagnostic performance with staged FFR as reference, and a moderate diagnostic performance with staged iFR as reference.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- FFR
- fractional flow reserve
- iFR
- instantaneous wave-free ratio
- QFR
- STEMI
Publication and Content Type
- art (subject category)
- ref (subject category)
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Sejr-Hansen, Mar ...
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Westra, Jelmer
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Thim, Troels
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Christiansen, Ev ...
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Eftekhari, Ashka ...
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Kristensen, Stee ...
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Jakobsen, Lars
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Götberg, Matthia ...
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Frøbert, Ole
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van der Hoeven, ...
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Holm, Niels Rams ...
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Maeng, Michael
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Catheterization ...
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Lund University