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Liver diseases in A...
Liver diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) : A population-based cohort study of 32,839 one-year survivors
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- Bonnesen, Trine Gade (författare)
- Aarhus University Hospital
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- Winther, Jeanette F. (författare)
- Danish Cancer Society
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- Andersen, Klaus K. (författare)
- Danish Cancer Society
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- Asdahl, Peter H. (författare)
- Aarhus University Hospital
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- de Fine Licht, Sofie (författare)
- Danish Cancer Society
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- Gudmundsdottir, Thorgerdur (författare)
- Danish Cancer Society
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- Sällfors Holmqvist, Anna (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Madanat-Harjuoja, Laura Maria (författare)
- Helsinki University Central Hospital,Finnish Cancer Registry
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- Tryggvadottir, Laufey (författare)
- Icelandic Cancer Registry,University of Iceland
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- Wesenberg, Finn (författare)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research,University of Oslo,Oslo university hospital
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- Heilmann, Carsten (författare)
- Copenhagen University Hospital
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- Olsen, Jørgen H. (författare)
- Danish Cancer Society
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- Hasle, Henrik (författare)
- Aarhus University Hospital
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(creator_code:org_t)
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- 2017-11-07
- 2018
- Engelska 7 s.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136. ; 142:4, s. 702-708
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Information on late onset liver complications after childhood cancer is scarce. To ensure an appropriate follow-up of childhood cancer survivors and reducing late liver complications, the need for comprehensive and accurate information is presented. We evaluate the risk of liver diseases in a large childhood cancer survivor cohort. We included all 1-year survivors of childhood cancer treated in the five Nordic countries. A Cox proportional hazards model was used to estimate hospitalisation rate (hazard) ratios (HRs) for each liver outcome according to type of cancer. We used the risk among survivors of central nervous system tumour as internal reference. With a median follow-up time of 10 years, 659 (2%) survivors had been hospitalised at least once for a liver disease. The risk for hospitalisation for any liver disease was high after hepatic tumour (HR = 6.9) and leukaemia (HR = 1.7). The Danish sub-cohort of leukaemia treated with haematopoietic stem cell transplantation had a substantially higher risk for hospitalisation for all liver diseases combined (HR = 3.8). Viral hepatitis accounted for 286 of 659 hospitalisations corresponding to 43% of all survivors hospitalised for liver disease. The 20-year cumulative risk of viral hepatitis was 1.8% for survivors diagnosed with cancer before 1990 but only 0.3% for those diagnosed after 1990. The risk of liver disease was low but significantly increased among survivors of hepatic tumours and leukaemia. Further studies with focus on the different treatment modalities are needed to further strengthen the prevention of treatment-induced late liver complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Bonnesen, Trine ...
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Winther, Jeanett ...
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Andersen, Klaus ...
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Asdahl, Peter H.
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de Fine Licht, S ...
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Gudmundsdottir, ...
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Sällfors Holmqvi ...
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Madanat-Harjuoja ...
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Tryggvadottir, L ...
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Wesenberg, Finn
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Heilmann, Carste ...
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Olsen, Jørgen H.
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Hasle, Henrik
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