Sökning: WFRF:(Borg Nicholas) >
Interval breast can...
-
Ugalde-Morales, EmilioKarolinska Institutet,Karolinska Institute
(författare)
Interval breast cancer is associated with interferon immune response
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:a8416386-ad1a-470a-87dc-aa039af2033a
-
https://lup.lub.lu.se/record/a8416386-ad1a-470a-87dc-aa039af2033aURI
-
https://doi.org/10.1016/j.ejca.2021.12.003DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:149687968URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Background: The aggressive nature of breast cancers detected between planned mammographic screens, so-called interval cancers, remains elusive. Here, we aim to characterise underlying molecular features of interval cancer. Methods: From 672 patients with invasive breast cancer, we analysed gene expression differences between 90 ‘true’ interval cancer cases (i.e. women with low-dense breasts defined as per cent mammographic density <25%) and 310 screen-detected tumours while accounting for PAM50 subtypes and thus overall tumour aggressiveness. We computed an interval cancer gene expression profile (IC-Gx) in a total of 2270 breast tumours (regardless of interval cancer status) and tested for association with expression-based immune subtypes in breast cancer. In addition, we investigated the contribution of inherited and somatic genetic variants in distinct features of interval cancer. Results: We identified 8331 genes nominally associated with interval cancer (P-value < 0.05, fold-change > 1.5). Gene set enrichment analysis showed immune-related pathways as key processes altered in interval cancer. Our IC-Gx, based on 47 genes with the strongest associations (false discovery rate < 0.05), was found to be associated mainly with immune subtypes involving interferon response. We isolated an interaction network of interval cancer and interferon genes for which a significant load of somatic and germline variants in class I interferon genes was observed. Conclusion: We identified novel molecular features of interval breast cancer highlighting interferon pathways as a potential target for prevention or treatment.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Grassmann, FelixKarolinska Institutet,Karolinska Institute,Health and Medical University
(författare)
-
Humphreys, KeithKarolinska Institutet,Karolinska Institute(Swepub:lu)med-khu
(författare)
-
Li, JingmeiKarolinska Institute,National University of Singapore,A*Star, Genome Institute of Singapore (GIS)
(författare)
-
Eriksson, MikaelKarolinska Institutet,Karolinska Institute
(författare)
-
Tobin, Nicholas P.Karolinska Institutet,Karolinska Institute(Swepub:lu)med-npt
(författare)
-
Lindström, Linda S.Karolinska Institutet,Karolinska Institute
(författare)
-
Vallon-Christersson, JohanLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-jvc
(författare)
-
Borg, ÅkeLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-abo
(författare)
-
Hall, PerKarolinska Institutet,Karolinska Institute
(författare)
-
Czene, KamilaKarolinska Institutet,Karolinska Institute
(författare)
-
Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:European Journal of Cancer: Elsevier BV162, s. 194-2050959-80491879-0852
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ugalde-Morales, ...
-
Grassmann, Felix
-
Humphreys, Keith
-
Li, Jingmei
-
Eriksson, Mikael
-
Tobin, Nicholas ...
-
visa fler...
-
Lindström, Linda ...
-
Vallon-Christers ...
-
Borg, Åke
-
Hall, Per
-
Czene, Kamila
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet