Search: WFRF:(Borg Nicholas) >
Interval breast can...
-
Ugalde-Morales, EmilioKarolinska Institutet,Karolinska Institute
(author)
Interval breast cancer is associated with interferon immune response
- Article/chapterEnglish2022
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:a8416386-ad1a-470a-87dc-aa039af2033a
-
https://lup.lub.lu.se/record/a8416386-ad1a-470a-87dc-aa039af2033aURI
-
https://doi.org/10.1016/j.ejca.2021.12.003DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:149687968URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background: The aggressive nature of breast cancers detected between planned mammographic screens, so-called interval cancers, remains elusive. Here, we aim to characterise underlying molecular features of interval cancer. Methods: From 672 patients with invasive breast cancer, we analysed gene expression differences between 90 ‘true’ interval cancer cases (i.e. women with low-dense breasts defined as per cent mammographic density <25%) and 310 screen-detected tumours while accounting for PAM50 subtypes and thus overall tumour aggressiveness. We computed an interval cancer gene expression profile (IC-Gx) in a total of 2270 breast tumours (regardless of interval cancer status) and tested for association with expression-based immune subtypes in breast cancer. In addition, we investigated the contribution of inherited and somatic genetic variants in distinct features of interval cancer. Results: We identified 8331 genes nominally associated with interval cancer (P-value < 0.05, fold-change > 1.5). Gene set enrichment analysis showed immune-related pathways as key processes altered in interval cancer. Our IC-Gx, based on 47 genes with the strongest associations (false discovery rate < 0.05), was found to be associated mainly with immune subtypes involving interferon response. We isolated an interaction network of interval cancer and interferon genes for which a significant load of somatic and germline variants in class I interferon genes was observed. Conclusion: We identified novel molecular features of interval breast cancer highlighting interferon pathways as a potential target for prevention or treatment.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Grassmann, FelixKarolinska Institutet,Karolinska Institute,Health and Medical University
(author)
-
Humphreys, KeithKarolinska Institutet,Karolinska Institute(Swepub:lu)med-khu
(author)
-
Li, JingmeiKarolinska Institute,A*Star, Genome Institute of Singapore (GIS),National University of Singapore
(author)
-
Eriksson, MikaelKarolinska Institutet,Karolinska Institute
(author)
-
Tobin, Nicholas P.Karolinska Institutet,Karolinska Institute(Swepub:lu)med-npt
(author)
-
Lindström, Linda S.Karolinska Institutet,Karolinska Institute
(author)
-
Vallon-Christersson, JohanLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-jvc
(author)
-
Borg, ÅkeLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-abo
(author)
-
Hall, PerKarolinska Institutet,Karolinska Institute
(author)
-
Czene, KamilaKarolinska Institutet,Karolinska Institute
(author)
-
Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
Related titles
-
In:European Journal of Cancer: Elsevier BV162, s. 194-2050959-80491879-0852
Internet link
Find in a library
To the university's database
- By the author/editor
-
Ugalde-Morales, ...
-
Grassmann, Felix
-
Humphreys, Keith
-
Li, Jingmei
-
Eriksson, Mikael
-
Tobin, Nicholas ...
-
show more...
-
Lindström, Linda ...
-
Vallon-Christers ...
-
Borg, Åke
-
Hall, Per
-
Czene, Kamila
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
European Journal ...
- By the university
-
Lund University
-
Karolinska Institutet