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  • Ugalde-Morales, EmilioKarolinska Institutet,Karolinska Institute (author)

Interval breast cancer is associated with interferon immune response

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022
  • 12 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:a8416386-ad1a-470a-87dc-aa039af2033a
  • https://lup.lub.lu.se/record/a8416386-ad1a-470a-87dc-aa039af2033aURI
  • https://doi.org/10.1016/j.ejca.2021.12.003DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149687968URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: The aggressive nature of breast cancers detected between planned mammographic screens, so-called interval cancers, remains elusive. Here, we aim to characterise underlying molecular features of interval cancer. Methods: From 672 patients with invasive breast cancer, we analysed gene expression differences between 90 ‘true’ interval cancer cases (i.e. women with low-dense breasts defined as per cent mammographic density <25%) and 310 screen-detected tumours while accounting for PAM50 subtypes and thus overall tumour aggressiveness. We computed an interval cancer gene expression profile (IC-Gx) in a total of 2270 breast tumours (regardless of interval cancer status) and tested for association with expression-based immune subtypes in breast cancer. In addition, we investigated the contribution of inherited and somatic genetic variants in distinct features of interval cancer. Results: We identified 8331 genes nominally associated with interval cancer (P-value < 0.05, fold-change > 1.5). Gene set enrichment analysis showed immune-related pathways as key processes altered in interval cancer. Our IC-Gx, based on 47 genes with the strongest associations (false discovery rate < 0.05), was found to be associated mainly with immune subtypes involving interferon response. We isolated an interaction network of interval cancer and interferon genes for which a significant load of somatic and germline variants in class I interferon genes was observed. Conclusion: We identified novel molecular features of interval breast cancer highlighting interferon pathways as a potential target for prevention or treatment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Grassmann, FelixKarolinska Institutet,Karolinska Institute,Health and Medical University (author)
  • Humphreys, KeithKarolinska Institutet,Karolinska Institute(Swepub:lu)med-khu (author)
  • Li, JingmeiKarolinska Institute,A*Star, Genome Institute of Singapore (GIS),National University of Singapore (author)
  • Eriksson, MikaelKarolinska Institutet,Karolinska Institute (author)
  • Tobin, Nicholas P.Karolinska Institutet,Karolinska Institute(Swepub:lu)med-npt (author)
  • Lindström, Linda S.Karolinska Institutet,Karolinska Institute (author)
  • Vallon-Christersson, JohanLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-jvc (author)
  • Borg, ÅkeLund University,Lunds universitet,Create Health,Annan verksamhet, LTH,Lunds Tekniska Högskola,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Other operations, LTH,Faculty of Engineering, LTH,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)onk-abo (author)
  • Hall, PerKarolinska Institutet,Karolinska Institute (author)
  • Czene, KamilaKarolinska Institutet,Karolinska Institute (author)
  • Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Related titles

  • In:European Journal of Cancer: Elsevier BV162, s. 194-2050959-80491879-0852

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