A systematic review of health-related quality of life in children and adolescents during treatment for cancer

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MARC

Bakker, AnneUtrecht University,Princess Maxima Center for Pediatric Oncology/Hematology (author)

A systematic review of health-related quality of life in children and adolescents during treatment for cancer

Article/chapterEnglish2023

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2023

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LIBRIS-ID:oai:lup.lub.lu.se:a8824a37-6d93-4ef4-9338-cfb87c58b629
https://lup.lub.lu.se/record/a8824a37-6d93-4ef4-9338-cfb87c58b629URI
https://doi.org/10.1016/j.ejcped.2023.100134DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:for swepub-publicationtype
Subject category:ref swepub-contenttype

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Health-related quality of life (HRQL) is a multidimensional concept which captures the individual’s perception of treatment burden. Evaluating HRQL during treatment for childhood cancer provides insight into the burden of the treatment from the child’s and/or parent’s perspective.In this review, we aimed to describe Patient-Reported Outcome Measures (PROMs) used to measure HRQL during treatment, describe how HRQL of paediatric oncology patients differs from the healthy norms, and describe biopsychosocial variables that are related to HRQL during treatment.We conducted a systematic review of HRQL of childhood cancer patients on treatment, according to PRISMA guidelines. We searched PubMed, EMBASE, PsycINFO and CINAHL, and after full-text review we included 85 papers (84 studies) with 7311 participants.These studies were conducted in 30 different countries and utilised 23 different PROMs. The most commonly used PROM was Pediatric Quality of Life generic core scales. While many different PROMs were used in the included studies, none of them covered all aspects of HRQL.We identified a lack of research regarding the effects of immuno- and CAR-T therapy and coping strategies of the child and/or the parents on HRQL, as well as a knowledge gap regarding HRQL in children below 2 years of age.All studies reported lower HRQL outcomes for patients in comparison to healthy children of siblings. Overall, children on treatment compared to off treatment reported lower HRQL. Described from a biopsychosocial perspective, we found inconsistent associations between other variables and HRQL outcomes. This can be explained by different studies classifying different groups differently.To be able to compare HRQL outcomes of childhood cancer patients internationally we recommend the use of a paediatric cancer PROM core set.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Streefkerk, NienkePrincess Maxima Center for Pediatric Oncology/Hematology (author)
Bakker, AnoukUtrecht University (author)
van Gorp, MarloesPrincess Maxima Center for Pediatric Oncology/Hematology (author)
van Litsenburg, Raphaele R.L.Princess Maxima Center for Pediatric Oncology/Hematology (author)
Grootenhuis, Martha A.Princess Maxima Center for Pediatric Oncology/Hematology (author)
Irestorm, ElinLund University,Lunds universitet,Pediatrisk onkologi,Forskargrupper vid Lunds universitet,Childhood Cancer Research Unit,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)el8544ir (author)
Utrecht UniversityPrincess Maxima Center for Pediatric Oncology/Hematology (creator_code:org_t)

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In:EJC Paediatric Oncology22772-610X

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

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By the university: Lund University

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