Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia.

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Brissot, Eolia (author)

Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia.

Article/chapterEnglish2015

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2014-12-19
Ferrata Storti Foundation (Haematologica),2015
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LIBRIS-ID:oai:lup.lub.lu.se:a8c70937-3457-415b-a70c-feae182ea910
https://lup.lub.lu.se/record/4905918URI
https://doi.org/10.3324/haematol.2014.116954DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

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This study aimed to determine the impact of tyrosine-kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia. This retrospective analysis from the Acute Leukemia Working Party of EBMT included 473 de novo Philadelphia chromosome-positive acute lymphoblastic leukemia patients in first complete remission who underwent an allogeneic stem cell transplantation using an human leucocyte antigen-identical sibling or human leucocyte antigen-matched unrelated donor between 2000 and 2010. Three hundred ninety patients received tyrosine-kinase inhibitors before transplant, 329 at induction and 274 at consolidation. The Kaplan-Meier estimates of leukemia-free survival, overall survival, cumulative incidences of relapse incidence, and non-relapse mortality at 5 years were 38%, 46%, 36% and 26%, respectively. In multivariate analysis, tyrosine-kinase inhibitors given before allogeneic stem cell transplantation was associated with a better overall survival (HR=0.68; P=.04) and was associated with lower relapse incidence (HR=0.5; P=.01). In the post-transplant period, multivariate analysis identified prophylactic tyrosine-kinase inhibitors administration to be a significant factor for improved leukemia-free survival (HR=0.44; P=.002) and overall survival (HR=0.42; P=.004), and a lower relapse incidence (HR=0.40; P=.01). In conclusion, over the past decade, tyrosine-kinase inhibitors administration before allogeneic stem cell transplantation has significantly improved the long term allogeneic stem cell transplantation outcome of adult Philadelphia chromosome-positive acute lymphoblastic leukemia. Prospective studies will be of great interest to further confirm the potential benefit of the prophylactic use of tyrosine-kinase inhibitors in the post-transplant setting.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Labopin, Myriam (author)
Beckers, Marielle M (author)
Socié, Gérard (author)
Rambaldi, Alessandro (author)
Volin, Liisa (author)
Finke, Jürgen (author)
Lenhoff, StigLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-slf (author)
Kröger, Nicolaus (author)
Ossenkoppele, Gert J (author)
Craddock, Charles F (author)
Yakoub-Agha, Ibrahim (author)
Gürman, Günhan (author)
Russell, Nigel H (author)
Aljurf, Mahmoud (author)
Potter, Michael N (author)
Nagler, Arnon (author)
Ottmann, Oliver (author)
Cornelissen, Jan J (author)
Esteve, Jordi (author)
Mohty, Mohamad (author)
Avdelningen för hematologi och transfusionsmedicinInstitutionen för laboratoriemedicin (creator_code:org_t)

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In:Haematologica: Ferrata Storti Foundation (Haematologica)100:3, s. 392-3991592-87210390-6078

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