Sökning: WFRF:(Shore Angela C) >
Reservoir Pressure ...
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Aizawa, KunihikoUniversity of Exeter
(författare)
Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:a95d6e37-bdc0-41f6-b3a0-8633cfcc34f2
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https://lup.lub.lu.se/record/a95d6e37-bdc0-41f6-b3a0-8633cfcc34f2URI
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https://doi.org/10.1161/HYPERTENSIONAHA.122.19483DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimated glomerular filtration rate in 542 older adults (69.4±7.9 years, 194 females) at baseline and after 3 years. Methods: Reservoir-excess pressure parameters, including reservoir pressure integral, excess pressure integral, systolic, and diastolic rate constants, were obtained by radial artery tonometry. Results: After 3 years, and in a group of 94 individuals (72.4±7.6 years, 26 females), there was an estimated glomerular filtration rate reduction of >5% per year (median reduction of 20.5% over 3 years). A multivariable logistic regression analysis revealed that higher baseline reservoir pressure integral was independently associated with a smaller reduction in estimated glomerular filtration rate after accounting for conventional cardiovascular risk factors and study centers (odds ratio: 0.660 [95% CIs, 0.494-0.883]; P=0.005). The association remained unchanged after further adjustments for potential confounders and baseline renal function (odds ratio: 0.528 [95% CIs, 0.351-0.794]; P=0.002). No other reservoir-excess pressure parameters exhibited associations with the reduction in renal function. Conclusions: This study demonstrates that baseline reservoir pressure integral was associated with the decline in renal function in older adults at 3-year follow-up, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hughes, Alun D.University College London
(författare)
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Casanova, FrancescoUniversity of Exeter
(författare)
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Gates, Phillip E.University of Exeter
(författare)
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Mawson, David M.University of Exeter
(författare)
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Gooding, Kim M.University of Exeter
(författare)
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Gilchrist, MarkUniversity of Exeter
(författare)
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Goncalves, IsabelLund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-igo
(författare)
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Nilsson, JanLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups(Swepub:lu)med-jn6
(författare)
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Khan, FaiselUniversity of Dundee
(författare)
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Colhoun, Helen M.University of Edinburgh
(författare)
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Palombo, CarloUniversity of Pisa
(författare)
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Parker, Kim H.Imperial College London
(författare)
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Shore, Angela C.University of Exeter
(författare)
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University of ExeterUniversity College London
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Hypertension79:10, s. 2364-23720194-911X
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Till lärosätets databas
- Av författaren/redakt...
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Aizawa, Kunihiko
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Hughes, Alun D.
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Casanova, France ...
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Gates, Phillip E ...
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Mawson, David M.
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Gooding, Kim M.
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visa fler...
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Gilchrist, Mark
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Goncalves, Isabe ...
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Nilsson, Jan
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Khan, Faisel
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Colhoun, Helen M ...
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Palombo, Carlo
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Parker, Kim H.
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Shore, Angela C.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Hypertension
- Av lärosätet
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Lunds universitet