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Inflammatory bowel ...
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Espinosa-Oliva, Ana M.University Hospital Virgen del Rocío,University of Seville
(author)
Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain
- Article/chapterEnglish2024
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:a977488c-ff06-4895-ba50-645b6d252815
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https://lup.lub.lu.se/record/a977488c-ff06-4895-ba50-645b6d252815URI
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https://doi.org/10.1111/nan.12962DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods: We have analysed the gut and the ventral midbrain from subjects previously diagnosed with IBD and form a DSS-based rat model of gut inflammation in terms of α-syn pathology. Results: Our data support the existence of pathogenic α-syn in both the gut and the brain, thus reinforcing the potential role of the ENS as a contributing factor in PD aetiology. Additionally, we have analysed the effect of a DSS-based rat model of gut inflammation to demonstrate (i) the appearance of P-α-syn inclusions in both Auerbach's and Meissner's plexuses (gut), (ii) an increase in α-syn expression in the ventral mesencephalon (brain) and (iii) the degeneration of nigral dopaminergic neurons, which all are considered classical hallmarks in PD. Conclusion: These results strongly support the plausibility of Braak's hypothesis and emphasise the significance of peripheral inflammation and the gut-brain axis in initiating α-syn aggregation and transport to the substantia nigra, resulting in neurodegeneration.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ruiz, RocíoUniversity of Seville,University Hospital Virgen del Rocío
(author)
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Soto, Manuel SarmientoUniversity of Seville,University Hospital Virgen del Rocío,University of Oxford
(author)
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Boza-Serrano, AntonioLund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Seville,University Hospital Virgen del Rocío(Swepub:lu)med-ab_
(author)
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Rodriguez-Perez, Ana I.CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),CIBER Enfermedades Neurodegenerativas (CIBERNED)
(author)
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Roca-Ceballos, María A.University of Seville,University Hospital Virgen del Rocío
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García-Revilla, JuanUniversity Hospital Virgen del Rocío,University of Seville
(author)
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Santiago, MartiUniversity of Seville,University Hospital Virgen del Rocío
(author)
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Serres, SébastienUniversity of Oxford,University of Nottingham
(author)
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Economopoulus, VasilikiUniversity of Oxford
(author)
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Carvajal, Ana E.University of Seville
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Vázquez-Carretero, María D.University of Seville
(author)
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García-Miranda, PabloUniversity of Seville
(author)
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Klementieva, OxanaLund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Medicinsk mikrospektroskopi,Forskargrupper vid Lunds universitet,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,LU profilområde: Proaktivt åldrande,Other operations, LTH,Faculty of Engineering, LTH,Medical Microspectroscopy,Lund University Research Groups,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,LU Profile Area: Proactive Ageing(Swepub:lu)med-oka
(author)
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Oliva-Martín, María J.University Hospital Virgen del Rocío,University of Seville
(author)
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Deierborg, TomasLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)expb-tol
(author)
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Rivas, EloyUniversity Hospital Virgen del Rocío
(author)
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Sibson, Nicola R.University of Oxford
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Labandeira-García, José L.CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),CIBER Enfermedades Neurodegenerativas (CIBERNED)
(author)
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Machado, AlbertoUniversity of Seville,University Hospital Virgen del Rocío
(author)
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Peral, María J.University of Seville
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Herrera, Antonio J.University Hospital Virgen del Rocío,University of Seville
(author)
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Venero, José L.University of Seville,University Hospital Virgen del Rocío
(author)
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de Pablos, Rocío M.University Hospital Virgen del Rocío,University of Seville
(author)
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University Hospital Virgen del RocíoUniversity of Seville
(creator_code:org_t)
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In:Neuropathology and Applied Neurobiology50:10305-1846
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Espinosa-Oliva, ...
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Ruiz, Rocío
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Soto, Manuel Sar ...
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Boza-Serrano, An ...
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Rodriguez-Perez, ...
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Roca-Ceballos, M ...
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García-Revilla, ...
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Santiago, Marti
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Serres, Sébastie ...
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Economopoulus, V ...
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Carvajal, Ana E.
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Vázquez-Carreter ...
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García-Miranda, ...
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Klementieva, Oxa ...
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Oliva-Martín, Ma ...
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Deierborg, Tomas
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Rivas, Eloy
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Sibson, Nicola R ...
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Labandeira-Garcí ...
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Machado, Alberto
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Peral, María J.
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Herrera, Antonio ...
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de Pablos, Rocío ...
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