Apoptosis in male germ cells in response to cyclin A1-deficiency and cell cycle arrest

Male mice homozygous for a mutated allele of the cyclin A 1 gene (Ccna 1) are sterile due to a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1(-1-) spermatocytes is associated with desynapsis abnormalities, lowered MPF activity, and apoptosis as evidenced by TUNEL-positive staining. With time, adult testicular tubules exhibit severe degeneration: some tubules in the older animals are almost devoid of germ cells at various stages of spermatogenesis. The mechanisms by which the cells sense the cell cycle arrest and the regulation of the decision to undergo cell death are under investigation. (C) 2003 Elsevier Inc. All rights reserved.

Liu, D (author)
Liao, ChingLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)extLU-1242 (author)
Batkiewicz, L (author)
Arbing, R (author)
Chung, SSW (author)
Lele, K (author)
Wolgemuth, DJ (author)
Patologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

By the author/editor: Salazar, G; Liu, D; Liao, Ching; Batkiewicz, L; Arbing, R; Chung, SSW; show more...; Lele, K; Wolgemuth, DJ; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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