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A large-scale genet...
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
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- Krüger, Rejko (author)
- University of Tübingen
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- Sharma, Manu (author)
- University of Tübingen
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- Riess, Olaf (author)
- University of Tübingen
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- Gasser, Thomas (author)
- University of Tübingen
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- Van Broeckhoven, Christine (author)
- University of Antwerp
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- Theuns, Jessie (author)
- University of Antwerp
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- Aasly, Jan (author)
- Norwegian University of Science and Technology
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- Annesi, Grazia (author)
- CNR: National Research Council of Italy
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- Bentivoglio, Anna Rita (author)
- Catholic University of the Sacred Heart, Rome
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- Brice, Alexis (author)
- Paris-Sorbonne University
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Djarmati, Ana (author)
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Elbaz, Alexis (author)
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Farrer, Matthew (author)
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Ferrarese, Carlo (author)
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Gibson, J. Mark (author)
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Hadjigeorgiou, Georgios M. (author)
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Hattori, Nobutaka (author)
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Ioannidis, John P A (author)
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Jasinska-Myga, Barbara (author)
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Klein, Christine (author)
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Lambert, Jean-Charles (author)
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Lesage, Suzanne (author)
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Lin, Juei-Jueng (author)
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Lynch, Timothy (author)
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Mellick, George D. (author)
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de Nigris, Francesa (author)
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Opala, Grzegorz (author)
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Prigione, Alessandro (author)
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Quattrone, Aldo (author)
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Ross, Owen A. (author)
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Satake, Wataru (author)
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Silburn, Peter A. (author)
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Tan, Eng-King (author)
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Toda, Tatsushi (author)
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Tomiyama, Hiroyuki (author)
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- Wirdefeldt, Karin (author)
- Karolinska Institutet
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Wszolek, Zbigniew K (author)
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Xiromerisiou, Georgia (author)
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Maraganore, Demetrius M. (author)
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- Puschmann, Andreas (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
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- Elsevier BV, 2011
- 2011
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 32:3, s. 9-548
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https://www.ncbi.nlm... (free)
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http://dx.doi.org/10...
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https://doi.org/10.1...
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Abstract
Subject headings
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- High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common Omi/HtrA2 variants in the Genetic Epidemiology of Parkinson's disease (GEO-PD) consortium. GEO-PD sites provided clinical and genetic data including affection status, gender, ethnicity, age at study, age at examination (all subjects); age at onset and family history of PD (patients). Genotyping was performed for the five most informative SNPs spanning the Omi/HtrA2 gene in approximately 2-3 kb intervals (rs10779958, rs2231250, rs72470544, rs1183739, rs2241028). Fixed as well as random effect models were used to provide summary risk estimates of Omi/HtrA2 variants. The 20 GEO-PD sites provided data for 6378 cases and 8880 controls. No overall significant associations for the five Omi/HtrA2 SNPs and PD were observed using either fixed effect or random effect models. The summary odds ratios ranged between 0.98 and 1.08 and the estimates of between-study heterogeneity were not large (non-significant Q statistics for all 5 SNPs; I(2) estimates 0-28%). Trends for association were seen for participants of Scandinavian descent for rs2241028 (OR 1.41, p=0.04) and for rs1183739 for age at examination (cut-off 65 years; OR 1.17, p=0.02), but these would not be significant after adjusting for multiple comparisons and their Bayes factors were only modest. This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Aged
- Chi-Square Distribution
- Cohort Studies
- European Continental Ancestry Group
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- International Cooperation
- Male
- Meta-Analysis as Topic
- Middle Aged
- Mitochondrial Proteins
- Parkinson Disease
- Polymorphism, Single Nucleotide
- Serine Endopeptidases
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Krüger, Rejko
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Sharma, Manu
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Riess, Olaf
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Gasser, Thomas
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Van Broeckhoven, ...
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Theuns, Jessie
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show more...
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Aasly, Jan
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Annesi, Grazia
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Bentivoglio, Ann ...
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Brice, Alexis
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Djarmati, Ana
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Elbaz, Alexis
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Farrer, Matthew
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Ferrarese, Carlo
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Gibson, J. Mark
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Hadjigeorgiou, G ...
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Hattori, Nobutak ...
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Ioannidis, John ...
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Jasinska-Myga, B ...
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Klein, Christine
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Lambert, Jean-Ch ...
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Lesage, Suzanne
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Lin, Juei-Jueng
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Lynch, Timothy
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Mellick, George ...
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de Nigris, Franc ...
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Opala, Grzegorz
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Prigione, Alessa ...
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Quattrone, Aldo
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Ross, Owen A.
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Satake, Wataru
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Silburn, Peter A ...
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Tan, Eng-King
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Toda, Tatsushi
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Tomiyama, Hiroyu ...
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Wirdefeldt, Kari ...
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Wszolek, Zbignie ...
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Xiromerisiou, Ge ...
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Maraganore, Deme ...
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Puschmann, Andre ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Neurobiology of ...
- By the university
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Lund University
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Karolinska Institutet