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Maternal Long-Chain...
Maternal Long-Chain Polyunsaturated Fatty Acid Status, Methylmercury Exposure, and Birth Outcomes in a High-Fish-Eating Mother-Child Cohort
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- Yeates, Alison Jayne (författare)
- University of Ulster
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- Zavez, Alexis (författare)
- University of Rochester
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- Thurston, Sally W. (författare)
- University of Rochester
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- McSorley, Emeir M. (författare)
- University of Ulster
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- Mulhern, Maria S. (författare)
- University of Ulster
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- Alhamdow, Ayman (författare)
- Karolinska Institute
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- Engström, Karin (författare)
- Lund University,Lunds universitet,EPI@LUND,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Wahlberg, Karin (författare)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Strain, J. J. (författare)
- University of Ulster
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- Watson, Gene E. (författare)
- University of Rochester
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- Myers, Gary J. (författare)
- University of Rochester
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- Davidson, Philip W. (författare)
- University of Rochester
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- Shamlaye, Conrad F. (författare)
- Ministry of Health, Seychelles
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- Broberg, Karin (författare)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- van Wijngaarden, Edwin (författare)
- University of Rochester
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 8 s.
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Ingår i: The Journal of nutrition. - : Elsevier BV. - 1541-6100 .- 0022-3166. ; 150:7, s. 1749-1756
- Relaterad länk:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Maternal status of long-chain PUFAs (LC-PUFAs) may be related to fetal growth. Maternal fish consumption exposes the mother to the neurotoxicant methylmercury (MeHg), which, in contrast, may restrict fetal growth. OBJECTIVE: Our aim was to examine relations between maternal LC-PUFA status at 28 wk and birth outcomes (birth weight, length, and head circumference), controlling for MeHg exposure throughout pregnancy, in the Seychelles Child Development Study Nutrition Cohort 2. Our secondary aim was to examine the influence of maternal variation in genes regulating the desaturation of LC-PUFAs [fatty acid desaturase (FADS)] on birth outcomes. METHODS: From nonfasting blood samples collected at 28 wk of gestation, we measured serum total LC-PUFA concentrations and FADS1 (rs174537, rs174561), FADS1-FADS2rs3834458, and FADS2rs174575 genotypes, with hair total mercury concentrations assessed at delivery. Data were available for n = 1236 mother-child pairs. Associations of maternal LC-PUFAs, MeHg, and FADS genotype with birth outcomes were assessed by multiple linear regression models, adjusting for child sex, gestational age, maternal age, BMI, alcohol use, socioeconomic status, and parity. RESULTS: In our cohort of healthy mothers, neither maternal LC-PUFA status nor MeHg exposure were significant determinants of birth outcomes. However, when compared with major allele homozygotes, mothers who were heterozygous for the minor allele of FADS1 (rs174537 and rs174561, GT compared with TT, β = 0.205, P = 0.03; TC compared with CC, β = 0.203, P = 0.04) and FADS1-FADS2 (rs3834458, Tdel compared with DelDel, β = 0.197, P = 0.04) had infants with a greater head circumference (all P < 0.05). Homozygosity for the minor allele of FADS2 (rs174575) was associated with a greater birth weight (GG compared with CC, β = 0.109, P = 0.04). CONCLUSIONS: In our mother-child cohort, neither maternal LC-PUFA status nor MeHg exposure was associated with birth outcomes. The observed associations of variation in maternal FADS genotype with birth outcomes should be confirmed in other populations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- birth outcomes
- fatty acid desaturase (FADS) genotype
- maternal nutrition; long chain polyunsaturated fatty acids
- methylmercury
- Seychelles Child Development Study
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Yeates, Alison J ...
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Zavez, Alexis
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Thurston, Sally ...
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McSorley, Emeir ...
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Mulhern, Maria S ...
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Alhamdow, Ayman
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visa fler...
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Engström, Karin
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Wahlberg, Karin
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Strain, J. J.
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Watson, Gene E.
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Myers, Gary J.
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Davidson, Philip ...
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Shamlaye, Conrad ...
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Broberg, Karin
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van Wijngaarden, ...
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