4,4′-Thiobis(2-tert-butyl-5-methylphenol), an antioxidant in medical devices that may cause allergic contact dermatitis

Antelmi, AnnaritaLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital (author)

Background: Antioxidants in medical devices, added to protect polymers or adhesives, may also cause contact dermatitis in some individuals. Objectives: To present data on sensitization to 4,4′-thiobis(2-tert-butyl-5-methylphenol), an antioxidant detected in some types of medical devices, for six patients that experienced eczematous reactions to different medical devices. Methods: Patch testing with 4,4′-thiobis(2-tert-butyl-5-methylphenol), 1% pet was performed. Gas chromatography-mass spectrometry (GC-MS) was used for identification of 4,4′-thiobis(2-tert-butyl-5-methylphenol) in different medical device products. Results: Six patients with contact allergy to 4,4′-thiobis(2-tert-butyl-5-methylphenol) also had relevant contact allergic reactions to medical devices containing the antioxidant. The presence of the antioxidant in products was detected using GC-MS analysis. Conclusions: The antioxidant 4,4′-thiobis(2-tert-butyl-5-methylphenol) may cause allergic contact dermatitis after exposure to different medical devices.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
antioxidant
CAS 96-69-5
contact dermatitis
EMLA
GC-MS
Kendall AMD
Lowinox
medical device
Santonox
Steri-strip
Tegaderm
wound care

Lejding, TinaLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-tlj (author)
Bruze, MagnusLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)derm-mbr (author)
Mowitz, MartinLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-mmw (author)
Dahlin, JakobLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)amk-jda (author)
Yrkes- och miljödermatologiForskargrupper vid Lunds universitet (creator_code:org_t)

By the author/editor: Antelmi, Annarit ...; Lejding, Tina; Bruze, Magnus; Mowitz, Martin; Dahlin, Jakob

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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