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Search: WFRF:(Zhang Huiping) > (2024) > PRL2 Phosphatase Pr...

  • Chen, HongxiaChongqing University,Northwestern University (author)

PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:abbd18ad-fc8f-48b1-af50-6d8a1802f25f
  • https://lup.lub.lu.se/record/abbd18ad-fc8f-48b1-af50-6d8a1802f25fURI
  • https://doi.org/10.1158/1541-7786.MCR-23-0115DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT signaling in leukemia cells, promoting their proliferation and survival. We found that PRL2 dephosphorylates CBL at tyrosine 371 and inhibits its activity toward KIT, leading to decreased KIT ubiquitination and enhanced AKT and ERK signaling in leukemia cells.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bai, YunpengPurdue University (author)
  • Kobayashi, MichihiroIndiana University (author)
  • Xiao, ShiyuNorthwestern University (author)
  • Barajas, SergioNorthwestern University,Indiana University (author)
  • Cai, WenjieIndiana University,Northwestern University (author)
  • Chen, SisiIndiana University (author)
  • Miao, JinminPurdue University (author)
  • Meke, Frederick NguelePurdue University (author)
  • Yao, ChonghuaIndiana University (author)
  • Yang, YuxiaPeking University,Indiana University (author)
  • Strube, KatherineIndiana University (author)
  • Satchivi, OdeliaIndiana University (author)
  • Sun, JianminLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)expk-jsu (author)
  • Ronnstrand, LarsLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär cancerforskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Cancer Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)klke-lro (author)
  • Croop, James M.Indiana University (author)
  • Boswell, H. ScottIndiana University (author)
  • Jia, YuzhiNorthwestern University (author)
  • Liu, HuipingNorthwestern University Feinberg School of Medicine,Northwestern University (author)
  • Li, Loretta S.Northwestern University Feinberg School of Medicine,Northwestern University (author)
  • Altman, Jessica K.Northwestern University Feinberg School of Medicine,Northwestern University (author)
  • Eklund, Elizabeth A.Northwestern University Feinberg School of Medicine,Jesse Brown VA Medical Center,Northwestern University (author)
  • Sukhanova, MadinaNorthwestern University (author)
  • Ji, PengNorthwestern University Feinberg School of Medicine,Northwestern University (author)
  • Tong, WeiThe Children's Hospital of Philadelphia (author)
  • Band, HamidUniversity of Nebraska Medical Center (author)
  • Huang, Danny T.Glasgow Royal Infirmary (author)
  • Platanias, Leonidas C.Northwestern University,Northwestern University Feinberg School of Medicine,Jesse Brown VA Medical Center (author)
  • Zhang, Zhong YinPurdue University (author)
  • Liu, YanNorthwestern University,Northwestern University Feinberg School of Medicine (author)
  • Chongqing UniversityNorthwestern University (creator_code:org_t)

Related titles

  • In:Molecular Cancer Research22:1, s. 94-1031541-7786

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