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PRL2 Phosphatase Pr...
PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation
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- Chen, Hongxia (author)
- Northwestern University,Chongqing University
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- Bai, Yunpeng (author)
- Purdue University
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- Kobayashi, Michihiro (author)
- Indiana University
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- Xiao, Shiyu (author)
- Northwestern University
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- Barajas, Sergio (author)
- Northwestern University,Indiana University
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- Cai, Wenjie (author)
- Northwestern University,Indiana University
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- Chen, Sisi (author)
- Indiana University
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- Miao, Jinmin (author)
- Purdue University
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- Meke, Frederick Nguele (author)
- Purdue University
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- Yao, Chonghua (author)
- Indiana University
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- Yang, Yuxia (author)
- Indiana University,Peking University
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- Strube, Katherine (author)
- Indiana University
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- Satchivi, Odelia (author)
- Indiana University
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- Sun, Jianmin (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
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- Ronnstrand, Lars (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär cancerforskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Cancer Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Croop, James M. (author)
- Indiana University
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- Boswell, H. Scott (author)
- Indiana University
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- Jia, Yuzhi (author)
- Northwestern University
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- Liu, Huiping (author)
- Northwestern University Feinberg School of Medicine,Northwestern University
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- Li, Loretta S. (author)
- Northwestern University,Northwestern University Feinberg School of Medicine
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- Altman, Jessica K. (author)
- Northwestern University Feinberg School of Medicine,Northwestern University
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- Eklund, Elizabeth A. (author)
- Northwestern University Feinberg School of Medicine,Jesse Brown VA Medical Center,Northwestern University
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- Sukhanova, Madina (author)
- Northwestern University
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- Ji, Peng (author)
- Northwestern University Feinberg School of Medicine,Northwestern University
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- Tong, Wei (author)
- The Children's Hospital of Philadelphia
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- Band, Hamid (author)
- University of Nebraska Medical Center
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- Huang, Danny T. (author)
- Glasgow Royal Infirmary
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- Platanias, Leonidas C. (author)
- Northwestern University Feinberg School of Medicine,Jesse Brown VA Medical Center,Northwestern University
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- Zhang, Zhong Yin (author)
- Purdue University
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- Liu, Yan (author)
- Northwestern University Feinberg School of Medicine,Northwestern University
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(creator_code:org_t)
- 2024
- 2024
- English 10 s.
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In: Molecular Cancer Research. - 1541-7786. ; 22:1, s. 94-103
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT signaling in leukemia cells, promoting their proliferation and survival. We found that PRL2 dephosphorylates CBL at tyrosine 371 and inhibits its activity toward KIT, leading to decreased KIT ubiquitination and enhanced AKT and ERK signaling in leukemia cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Chen, Hongxia
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Bai, Yunpeng
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Kobayashi, Michi ...
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Xiao, Shiyu
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Barajas, Sergio
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Cai, Wenjie
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show more...
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Chen, Sisi
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Miao, Jinmin
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Meke, Frederick ...
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Yao, Chonghua
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Yang, Yuxia
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Strube, Katherin ...
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Satchivi, Odelia
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Sun, Jianmin
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Ronnstrand, Lars
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Croop, James M.
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Boswell, H. Scot ...
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Jia, Yuzhi
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Liu, Huiping
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Li, Loretta S.
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Altman, Jessica ...
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Eklund, Elizabet ...
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Sukhanova, Madin ...
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Ji, Peng
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Tong, Wei
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Band, Hamid
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Huang, Danny T.
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Platanias, Leoni ...
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Zhang, Zhong Yin
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Liu, Yan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Molecular Cancer ...
- By the university
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Lund University