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A link between GIP ...
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Ahlqvist, EmmaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
(author)
A link between GIP and osteopontin in adipose tissue and insulin resistance.
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-05-17
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American Diabetes Association,2013
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:ac1031b5-93ba-4bcc-aee4-80f618c0a647
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https://lup.lub.lu.se/record/3438299URI
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https://doi.org/10.2337/db12-0976DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Low grade inflammation in obesity is associated with accumulation of the macrophagederived cytokine osteopontin in adipose tissue and induction of local as well as systemic insulin resistance. Since GIP (glucose-dependent insulinotropic polypeptide) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate osteopontin (OPN) expression in adipose tissue and thereby induce insulin resistance. GIP stimulated OPN protein expression in a dose-dependent fashion in rat primary adipocytes. The level of OPN mRNA was higher in adipose tissue of obese individuals (0.13±}0.04 vs 0.04±}0.01, P<0.05) and correlated inversely with measures of insulin sensitivity (r=-0.24, P=0.001). A common variant of the GIP receptor (GIPR) (rs10423928) gene was associated with lower amount of the exon 9 containing isoform required for transmembrane activity. Carriers of the A-allele with a reduced receptor function showed lower adipose tissue OPN mRNA levels and better insulin sensitivity. Together, these data suggest a role for GIP not only as an incretin hormone, but also as a trigger of inflammation and insulin resistance in adipose tissue. Carriers of GIPR rs10423928 A-allele showed protective properties via reduced GIP effects. Identification of this unprecedented link between GIP and OPN in adipose tissue might open new avenues for therapeutic interventions.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Osmark, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)medk-pos
(author)
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Kuulasmaa, TiinaUniversity of Eastern Finland
(author)
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Pilgaard, KasperSteno Diabetes Center Copenhagen
(author)
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Omar, BilalLund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bor
(author)
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Brøns, CharlotteSteno Diabetes Center Copenhagen
(author)
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Kotova, OlgaLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)med-oak
(author)
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Zetterqvist, AnnaLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)med-aaz
(author)
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Stancáková, AlenaUniversity of Eastern Finland
(author)
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Jonsson, AnnaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-jsa
(author)
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Hansson, OlaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)medk-oha
(author)
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Kuusisto, JohannaUniversity of Eastern Finland
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Kieffer, Timothy JUniversity of British Columbia
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Tuomi, TiinamaijaUniversity of Helsinki,Folkhälsan Research Center
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Isomaa, BoDepartment of Social Services and Health Care, Jakobstad,Folkhälsan Research Center
(author)
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Madsbad, StenUniversity of Copenhagen
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Gomez, Maria FLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)mphy-mgo
(author)
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Poulsen, PernilleSteno Diabetes Center Copenhagen
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Laakso, MarkkuUniversity of Eastern Finland
(author)
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Degerman, EvaLund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups(Swepub:lu)medk-ede
(author)
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Pihlajamäki, JussiUniversity of Eastern Finland
(author)
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Wierup, NilsLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)mphy-nwi
(author)
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Vaag, AllanLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-ava
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Diabetes: American Diabetes Association62:6, s. 2088-20941939-327X0012-1797
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Ahlqvist, Emma
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Osmark, Peter
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Kuulasmaa, Tiina
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Pilgaard, Kasper
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Omar, Bilal
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Brøns, Charlotte
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Kotova, Olga
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Zetterqvist, Ann ...
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Stancáková, Alen ...
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Jonsson, Anna
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Hansson, Ola
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Kuusisto, Johann ...
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Kieffer, Timothy ...
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Tuomi, Tiinamaij ...
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Isomaa, Bo
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Madsbad, Sten
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Gomez, Maria F
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Poulsen, Pernill ...
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Laakso, Markku
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Degerman, Eva
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Pihlajamäki, Jus ...
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Wierup, Nils
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Vaag, Allan
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Groop, Leif
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Lyssenko, Valeri ...
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