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A link between GIP ...
A link between GIP and osteopontin in adipose tissue and insulin resistance.
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Osmark, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Kuulasmaa, Tiina (author)
- University of Eastern Finland
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- Pilgaard, Kasper (author)
- Steno Diabetes Center Copenhagen
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- Omar, Bilal (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Brøns, Charlotte (author)
- Steno Diabetes Center Copenhagen
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- Kotova, Olga (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Zetterqvist, Anna (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Stancáková, Alena (author)
- University of Eastern Finland
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- Jonsson, Anna (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Hansson, Ola (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Kuusisto, Johanna (author)
- University of Eastern Finland
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- Kieffer, Timothy J (author)
- University of British Columbia
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- Tuomi, Tiinamaija (author)
- University of Helsinki,Folkhälsan Research Center
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- Isomaa, Bo (author)
- Department of Social Services and Health Care, Jakobstad,Folkhälsan Research Center
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- Madsbad, Sten (author)
- University of Copenhagen
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- Gomez, Maria F (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Poulsen, Pernille (author)
- Steno Diabetes Center Copenhagen
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- Laakso, Markku (author)
- University of Eastern Finland
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- Degerman, Eva (author)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
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- Pihlajamäki, Jussi (author)
- University of Eastern Finland
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- Wierup, Nils (author)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine
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- Vaag, Allan (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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(creator_code:org_t)
- 2013-05-17
- 2013
- English.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 62:6, s. 2088-2094
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://diabetes.dia...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Low grade inflammation in obesity is associated with accumulation of the macrophagederived cytokine osteopontin in adipose tissue and induction of local as well as systemic insulin resistance. Since GIP (glucose-dependent insulinotropic polypeptide) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate osteopontin (OPN) expression in adipose tissue and thereby induce insulin resistance. GIP stimulated OPN protein expression in a dose-dependent fashion in rat primary adipocytes. The level of OPN mRNA was higher in adipose tissue of obese individuals (0.13±}0.04 vs 0.04±}0.01, P<0.05) and correlated inversely with measures of insulin sensitivity (r=-0.24, P=0.001). A common variant of the GIP receptor (GIPR) (rs10423928) gene was associated with lower amount of the exon 9 containing isoform required for transmembrane activity. Carriers of the A-allele with a reduced receptor function showed lower adipose tissue OPN mRNA levels and better insulin sensitivity. Together, these data suggest a role for GIP not only as an incretin hormone, but also as a trigger of inflammation and insulin resistance in adipose tissue. Carriers of GIPR rs10423928 A-allele showed protective properties via reduced GIP effects. Identification of this unprecedented link between GIP and OPN in adipose tissue might open new avenues for therapeutic interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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Diabetes
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- By the author/editor
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Ahlqvist, Emma
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Osmark, Peter
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Kuulasmaa, Tiina
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Pilgaard, Kasper
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Omar, Bilal
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Brøns, Charlotte
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show more...
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Kotova, Olga
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Zetterqvist, Ann ...
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Stancáková, Alen ...
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Jonsson, Anna
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Hansson, Ola
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Kuusisto, Johann ...
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Kieffer, Timothy ...
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Tuomi, Tiinamaij ...
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Isomaa, Bo
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Madsbad, Sten
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Gomez, Maria F
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Poulsen, Pernill ...
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Laakso, Markku
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Degerman, Eva
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Pihlajamäki, Jus ...
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Wierup, Nils
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Vaag, Allan
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Groop, Leif
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Lyssenko, Valeri ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes
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Lund University