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  • Lörinc, EsterLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups (author)

Ki67 and p53 immunohistochemistry reduces interobserver variation in assessment of Barrett's oesophagus.

  • Article/chapterEnglish2005

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  • Wiley,2005

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  • LIBRIS-ID:oai:lup.lub.lu.se:aceba039-036e-47b6-ac31-3d1280eeff77
  • https://lup.lub.lu.se/record/137870URI
  • https://doi.org/10.1111/j.1365-2559.2005.02139.xDOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

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  • Aims: To devise clinically applicable methods for assessing p53 and Ki67 immunohistochemical (IHC) reactivity in Barrett's oesophagus (BE) and to compare the interobserver agreement between these methods and routine haematoxylin and eosin (H&E) evaluation. Methods and results: One hundred and fifteen biopsies diagnosed as BE, selected from the files of the University Hospital MAS, Malmö, were re-evaluated for dysplasia by three pathologists. For IHC analysis areas with the most prominent positivity were evaluated. The mean of p53+ epithelial nuclei/high-power field (HPF) was obtained by counting between 1 and 5 HPFs/biopsy. A proliferation quotient (PQ) was obtained by dividing the number of Ki67+ epithelial nuclei in the upper half by the lower half of the mucosa, using two HPFs. Mean κ values were 0.24, 0.71 and 0.52 for H&E, p53 and Ki67 evaluations, respectively. There was a correlation between increasing severity of dysplasia, IHC measurable overexpression of p53 and shift of the mucosal proliferation zone towards the surface, measured as PQ. Conclusions: The described methods for p53 and Ki67 evaluation are more reproducible than routine H&E evaluation of BE. Furthermore, the IHC methods correlate with the severity of dysplasia and are useful supplementary prognostic markers.

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  • Jakobsson, B (author)
  • Landberg, GöranLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-gla (author)
  • Veress, BelaLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-bve (author)
  • Patologi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

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  • In:Histopathology: Wiley46:6, s. 642-6480309-01671365-2559

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By the author/editor
Lörinc, Ester
Jakobsson, B
Landberg, Göran
Veress, Bela
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Cell and Molecul ...
Articles in the publication
Histopathology
By the university
Lund University

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