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  • dos Santos, CristianeUniversity of Campinas (author)

Excess of glucocorticoids during late gestation impairs the recovery of offspring’s β-cell function after a postnatal injury

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021

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  • LIBRIS-ID:oai:lup.lub.lu.se:ad1d8d39-c085-406e-8581-4cda2c3271c8
  • https://lup.lub.lu.se/record/ad1d8d39-c085-406e-8581-4cda2c3271c8URI
  • https://doi.org/10.1096/fj.202100841RDOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Since prenatal glucocorticoids (GC) excess increases the risk of metabolic dysfunctions in the offspring and its effect on β-cell recovery capacity remains unknown we investigated these aspects in offspring from mice treated with dexamethasone (DEX) in the late pregnancy. Half of the pups were treated with streptozotocin (STZ) on the sixth postnatal day (PN). Functional and molecular analyses were performed in male offspring on PN25 and PN225. Prenatal DEX treatment resulted in low birth weight. At PN25, both the STZ-treated offspring developed hyperglycemia and had lower β-cell mass, in parallel with higher α-cell mass and glucose intolerance, with no impact of prenatal DEX on such parameters. At PN225, the β-cell mass was partially recovered in the STZ-treated mice, but they remained glucose-intolerant, irrespective of being insulin sensitive. Prenatal exposition to DEX predisposed adult offspring to sustained hyperglycemia and perturbed islet function (lower insulin and higher glucagon response to glucose) in parallel with exacerbated glucose intolerance. β-cell-specific knockdown of the Hnf4α in mice from the DS group resulted in exacerbated glucose intolerance. We conclude that high GC exposure during the prenatal period exacerbates the metabolic dysfunctions in adult life of mice exposed to STZ early in life, resulting in a lesser ability to recover the islets’ function over time. This study alerts to the importance of proper management of exogenous GCs during pregnancy and a healthy postnatal lifestyle since the combination of adverse factors during the prenatal and postnatal period accentuates the predisposition to metabolic disorders in adult life.

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  • Rafacho, AlexFederal University of Santa Catarina (author)
  • Ferreira, Sandra MaraUniversity of Campinas (author)
  • Vettorazzi, Jean FranciescoUniversity of Campinas (author)
  • dos Reis Araújo, ThiagoUniversity of Campinas (author)
  • Mateus Gonçalves, LucianaUniversity of Campinas (author)
  • Ruhrmann, SabrinaLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)sa4447ru (author)
  • Bacos, KarlLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medk-kb0 (author)
  • Ling, CharlotteLund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-cl0 (author)
  • Boschero, Antônio CarlosUniversity of Campinas (author)
  • Jorge dos Santos, GustavoFederal University of Santa Catarina (author)
  • University of CampinasFederal University of Santa Catarina (creator_code:org_t)

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  • In:FASEB Journal35:80892-6638

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