Sökning: WFRF:(Nordström Annika) >
Bisphosphonate Use ...
Bisphosphonate Use After Hip Fracture in Older Adults : A Nationwide Retrospective Cohort Study
-
- Nordström, Peter (författare)
- Umeå universitet,Umeå University,Geriatrik,Department of Community Medicine and Rehabilitation, Geriatrics, Umeå, Sweden
-
- Toots, Annika (författare)
- Umeå universitet,Umeå University,Geriatrik,Fysioterapi,Department of Community Medicine and Rehabilitation, Geriatrics, Umeå, Sweden; Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå, Sweden
-
- Gustafson, Yngve (författare)
- Umeå universitet,Umeå University,Geriatrik,Department of Community Medicine and Rehabilitation, Geriatrics, Umeå, Sweden
-
visa fler...
-
- Thorngren, Karl Göran (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Orthopedics, Lund University, Lund, Sweden
-
- Hommel, Ami (författare)
- Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine,Department of Clinical Sciences, Orthopedics, Lund University, Lund, Sweden
-
- Nordström, Anna (författare)
- Umeå universitet,Umeå University,Yrkes- och miljömedicin,Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
-
Ingår i: Journal of the American Medical Directors Association. - : Elsevier BV. - 1525-8610 .- 1538-9375. ; 18:6, s. 515-521
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives: The aim of this study was to investigate the association between bisphosphonate use and the risk of new fracture in a nationwide cohort of individuals with previous hip fractures, with emphasis on individuals above 80 years of age. Design, setting, and participants: From a nationwide cohort with hip fracture (2006-2012) (n = 93, 601), each individual prescribed bisphosphonates after hip fracture (n = 5845) was matched with up to three individuals not prescribed bisphosphonates, resulting in a cohort of 21,363 individuals. Main outcome measure: A new hip fracture. Results: During a mean follow-up period of 2.98 (range, 0.02-8) years, 4581 fractures occurred in the cohort. Before the initiation of bisphosphonate therapy, individuals later prescribed bisphosphonates had an increased risk of hip fracture (multivariable adjusted odds ratio [OR], 2.63; 95% confidence interval [CI], 2.23-3.24) compared with controls. In the period after bisphosphonate therapy initiation, individuals prescribed bisphosphonates had a lower risk of hip fracture (multivariable adjusted hazard ratio [HR], 0.76; 95% CI, 0.65-0.90) compared with controls. Similar effects were seen after the initiation of bisphosphonates in individuals aged more than 80 years (HR, 0.79; 95% CI, 0.62-0.99). In contrast, the initiation of bisphosphonate therapy did not influence the risk of injurious falls not resulting in fracture (HR, 0.95; 95% CI, 0.86-1.05). Conclusion: Bisphosphonate use was associated with a decreased risk of hip fracture in this nationwide cohort of older men and women, with similar risk reductions in individuals older than 80 years.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Bisphosphonates
- Cohort study
- Hip fractures
- Older individuals
- Hip fractures
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas