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Proteomic Determina...
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Gangwar, AnamikaUniversity of Texas Southwestern Medical Center
(författare)
Proteomic Determinants of Variation in Cholesterol Efflux : Observations from the Dallas Heart Study
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:ae29303c-13e7-4e07-86ba-c6e70216e05e
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https://lup.lub.lu.se/record/ae29303c-13e7-4e07-86ba-c6e70216e05eURI
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https://doi.org/10.3390/ijms242115526DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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High-density lipoproteins (HDLs) are promising targets for predicting and treating atherosclerotic cardiovascular disease (ASCVD), as they mediate removal of excess cholesterol from lipid-laden macrophages that accumulate in the vasculature. This functional property of HDLs, termed cholesterol efflux capacity (CEC), is inversely associated with ASCVD. HDLs are compositionally diverse, associating with >250 different proteins, but their relative contribution to CEC remains poorly understood. Our goal was to identify and define key HDL-associated proteins that modulate CEC in humans. The proteomic signature of plasma HDL was quantified in 36 individuals in the multi-ethnic population-based Dallas Heart Study (DHS) cohort that exhibited persistent extremely high (>=90th%) or extremely low CEC (<=10th%) over 15 years. Levels of apolipoprotein (Apo)A-I associated ApoC-II, ApoC-III, and ApoA-IV were differentially correlated with CEC in high (r = 0.49, 0.41, and −0.21 respectively) and low (r = −0.46, −0.41, and 0.66 respectively) CEC groups (p for heterogeneity (pHet) = 0.03, 0.04, and 0.003 respectively). Further, we observed that levels of ApoA-I with ApoC-III, complement C3 (CO3), ApoE, and plasminogen (PLMG) were inversely associated with CEC in individuals within the low CEC group (r = −0.11 to −0.25 for subspecies with these proteins vs. r = 0.58 to 0.65 for subspecies lacking these proteins; p < 0.05 for heterogeneity). These findings suggest that enrichment of specific proteins on HDLs and, thus, different subspecies of HDLs, differentially modulate the removal of cholesterol from the vasculature.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Deodhar, Sneha S.University of Texas Southwestern Medical Center
(författare)
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Saldanha, SuzanneUniversity of Texas Southwestern Medical Center
(författare)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome
(författare)
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Abbasi, FahimStanford University School of Medicine
(författare)
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Pearce, Ryan W.Quest Diagnostics Cardiometabolic Center of Excellence
(författare)
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Collier, Timothy S.Quest Diagnostics Cardiometabolic Center of Excellence
(författare)
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McPhaul, Michael J.Quest Diagnostics
(författare)
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Furtado, Jeremy D.Biogen, Inc.
(författare)
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Sacks, Frank M.Harvard University
(författare)
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Merrill, Nathaniel J.Pacific Northwest National Laboratory
(författare)
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McDermott, Jason E.Pacific Northwest National Laboratory
(författare)
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Melchior, John T.Oregon Health & Science University,University of Cincinnati
(författare)
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Rohatgi, AnandUniversity of Texas Southwestern Medical Center
(författare)
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University of Texas Southwestern Medical CenterKardiovaskulär forskning - hypertoni
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Molecular Sciences24:211661-6596
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Gangwar, Anamika
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Deodhar, Sneha S ...
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Saldanha, Suzann ...
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Melander, Olle
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Abbasi, Fahim
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Pearce, Ryan W.
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Collier, Timothy ...
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McPhaul, Michael ...
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Furtado, Jeremy ...
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Sacks, Frank M.
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Merrill, Nathani ...
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McDermott, Jason ...
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Melchior, John T ...
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Rohatgi, Anand
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