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  • Have Beck, IbenUniversity of Southern Denmark (författare)

Association Between Prenatal and Early Postnatal Exposure to Perfluoroalkyl Substances and IQ Score in 7-Year-Old Children From the Odense Child Cohort

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:ae3c373d-8d80-483b-85fd-3e032fc2bf82
  • https://lup.lub.lu.se/record/ae3c373d-8d80-483b-85fd-3e032fc2bf82URI
  • https://doi.org/10.1093/aje/kwad110DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Perfluoroalkyl substances (PFAS) are persistent chemicals capable of crossing the placenta and passing into breast milk. Evidence suggests that PFAS exposure may affect brain development. We investigated whether prenatal or early postnatal PFAS exposure was associated with intelligence quotient (IQ) scores in schoolchildren from the Odense Child Cohort (Denmark, 2010–2020). We assessed concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) in maternal serum collected during the first trimester of pregnancy and in child serum at age 18 months. At 7 years of age, children completed an abbreviated version of the Wechsler Intelligence Scale for Children, Fifth Edition, from which Full Scale Intelligence Quotient (FSIQ) and Verbal Comprehension Index scores were estimated. In multiple linear regression analyses conducted among 967 mother-child pairs, a doubling in maternal PFOS and PFNA concentrations was associated with a lower FSIQ score, while no significant associations were observed for PFOA, PFHxS, or PFDA. PFAS concentrations at age 18 months and duration of breastfeeding were strongly correlated, and even in structural equation models it was not possible to differentiate between the opposite effects of PFAS exposure and duration of breastfeeding on FSIQ. PFAS exposure is ubiquitous; therefore, an association with even a small reduction in IQ is of public health concern.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bilenberg, NielsRegion Syddanmark (författare)
  • Möller, SörenUniversity of Southern Denmark (författare)
  • Nielsen, FlemmingUniversity of Southern Denmark (författare)
  • Grandjean, PhilippeHarvard University (författare)
  • Damsgaard Hojsager, FrederikUniversity of Southern Denmark (författare)
  • Ingi Halldorsson, ThorhallurDanish Serum Institute, Copenhagen (författare)
  • Nielsen, ChristelLund University,Lunds universitet,Epidemiologi,Forskargrupper vid Lunds universitet,Epidemiology,Lund University Research Groups(Swepub:lu)med-cin (författare)
  • Kold Jensen, TinaUniversity of Southern Denmark (författare)
  • University of Southern DenmarkRegion Syddanmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Epidemiology192:9, s. 1522-15350002-9262

Internetlänk

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