SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Andersen Anne Marie Nybo)
 

Sökning: WFRF:(Andersen Anne Marie Nybo) > Fetal exposure to m...

  • Hærvig, Katia KeglbergCopenhagen University Hospital (författare)

Fetal exposure to maternal cigarette smoking and male reproductive function in young adulthood

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-04-27
  • Springer Science and Business Media LLC,2022
  • 14 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:af25aef8-bb50-485e-82f8-3ee73a8fdfd3
  • https://lup.lub.lu.se/record/af25aef8-bb50-485e-82f8-3ee73a8fdfd3URI
  • https://doi.org/10.1007/s10654-022-00869-2DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Maternal smoking during pregnancy constitutes a potential, major risk factor for adult male reproductive function. In the hitherto largest longitudinal cohort, we examined biomarkers of reproductive function according to maternal smoking during the first trimester and investigated whether associations were mitigated by smoking cessation prior to the fetal masculinization programming window. Associations between exposure to maternal smoking and semen characteristics, testicular volume and reproductive hormones were assessed among 984 young men from the Fetal Programming of Semen Quality (FEPOS) cohort. Maternal smoking was assessed through interview data and measured plasma cotinine levels during pregnancy. We applied negative binomial, logistic and linear regression models to estimate differences in outcomes according to levels of maternal smoking. Sons of light smokers (≤ 10 cigarettes/day) had a 19% (95% CI − 29%, − 6%) lower sperm concentration and a 24% (95% CI − 35%, − 11%) lower total sperm count than sons of non-smokers. These estimates were 38% (95% CI − 52%, − 22%) and 33% (95% CI − 51%, − 8%), respectively, for sons of heavy smokers (> 10 cigarettes/day). The latter group also had a 25% (95% CI 1%, 54%) higher follitropin level. Similarly, sons exposed to maternal cotinine levels of > 10 ng/mL had lower sperm concentration and total sperm count. Smoking cessation prior to gestational week seven was not associated with a higher reproductive capacity. We observed substantial and consistent exposure–response associations, providing strong support for the hypothesis that maternal smoking impairs male reproductive function. This association persisted regardless of smoking cessation in early pregnancy.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Petersen, Kajsa UgelvigCopenhagen University Hospital (författare)
  • Giwercman, AleksanderLund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproduktionsmedicin, Malmö,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Reproductive medicine, Malmö(Swepub:lu)kir-agi (författare)
  • Hougaard, Karin SørigUniversity of Copenhagen,The National Research Centre for the Working Environment (författare)
  • Høyer, Birgit BjerreCopenhagen University Hospital (författare)
  • Lindh, ChristianLund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-cli (författare)
  • Ramlau-Hansen, Cecilia HøstAarhus University (författare)
  • Nybo Andersen, Anne MarieUniversity of Copenhagen (författare)
  • Toft, GunnarAarhus University Hospital (författare)
  • Bonde, Jens PeterUniversity of Copenhagen,Copenhagen University Hospital (författare)
  • Tøttenborg, Sandra SøgaardCopenhagen University Hospital,University of Copenhagen (författare)
  • Copenhagen University HospitalMolekylärgenetisk reproduktionsmedicin, Malmö (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Epidemiology: Springer Science and Business Media LLC37:5, s. 525-5380393-29901573-7284

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy