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  • Falcone, Guido J. (author)

Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:af705086-f48f-48b9-9d5a-8ef641ccb871
  • https://lup.lub.lu.se/record/3388415URI
  • https://doi.org/10.1161/STROKEAHA.112.659755DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background and Purpose-Genetic variation influences risk of intracerebral hemorrhage (ICH). Hypertension (HTN) is a potent risk factor for ICH and several common genetic variants (single nucleotide polymorphisms [SNPs]) associated with blood pressure levels have been identified. We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN. Methods-We conducted a prospective multicenter case-control study in 2272 subjects of European ancestry (1025 cases and 1247 control subjects). Thirty-nine SNPs reported to be associated with blood pressure levels were identified from the National Human Genome Research Institute genomewide association study catalog. Single-SNP association analyses were performed for the outcomes ICH and pre-ICH HTN. Subsequently, weighted and unweighted genetic risk scores were constructed using these SNPs and entered as the independent variable in logistic regression models with ICH and pre-ICH HTN as the dependent variables. Results-No single SNP was associated with either ICH or pre-ICH HTN. The blood pressure-based unweighted genetic risk score was associated with risk of ICH (OR, 1.11; 95% CI, 1.02-1.21; P=0.01) and the subset of ICH in deep regions (OR, 1.18; 95% CI, 1.07-1.30; P=0.001), but not with the subset of lobar ICH. The score was associated with a history of HTN among control subjects (OR, 1.17; 95% CI, 1.04-1.31; P=0.009) and ICH cases (OR, 1.15; 95% CI, 1.01-1.31; P=0.04). Similar results were obtained when using a weighted score. Conclusion-Increasing numbers of high blood pressure-related alleles are associated with increased risk of deep ICH as well as with clinically identified HTN. (Stroke. 2012; 43: 2877-2883.)

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Biffi, Alessandro (author)
  • Devan, William J. (author)
  • Jagiella, Jeremiasz M. (author)
  • Schmidt, Helena (author)
  • Kissela, Brett (author)
  • Hansen, BjörnLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-bhe (author)
  • Jimenez-Conde, Jordi (author)
  • Giralt-Steinhauer, Eva (author)
  • Elosua, Roberto (author)
  • Cuadrado-Godia, Elisa (author)
  • Soriano, Carolina (author)
  • Ayres, Alison M. (author)
  • Schwab, Kristin (author)
  • Pera, Joanna (author)
  • Urbanik, Andrzej (author)
  • Rost, Natalia S. (author)
  • Goldstein, Joshua N. (author)
  • Viswanathan, Anand (author)
  • Pichler, Alexander (author)
  • Enzinger, Christian (author)
  • Norrving, BoLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-bno (author)
  • Tirschwell, David L. (author)
  • Selim, Magdy (author)
  • Brown, Devin L. (author)
  • Silliman, Scott L. (author)
  • Worrall, Bradford B. (author)
  • Meschia, James F. (author)
  • Kidwell, Chelsea S. (author)
  • Montaner, Joan (author)
  • Fernandez-Cadenas, Israel (author)
  • Delgado, Pilar (author)
  • Broderick, Joseph P. (author)
  • Greenberg, Steven M. (author)
  • Roquer, Jaume (author)
  • Lindgren, ArneLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-ali (author)
  • Slowik, Agnieszka (author)
  • Schmidt, Reinhold (author)
  • Flaherty, Matthew L. (author)
  • Kleindorfer, Dawn O. (author)
  • Langefeld, Carl D. (author)
  • Woo, Daniel (author)
  • Rosand, Jonathan (author)
  • Neurologi, LundSektion IV (creator_code:org_t)

Related titles

  • In:Stroke: a journal of cerebral circulation43:11, s. 2877-28831524-4628

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