(WFRF:(Smedby Karin E.)) pers:(Pospisilova Sarka) pers:(Lefranc Marie Paule)
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Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.
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- Baliakas, Panagiotis (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi
- Agathangelidis, Andreas (author)
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- Hadzidimitriou, Anastasia (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
- show more...
- Minga, Eva (author)
- Tsanousa, Athina (author)
- Scarfò, Lydia (author)
- Davis, Zadie (author)
- Yan, Xiao-Jie (author)
- Shanafelt, Tait (author)
- Plevova, Karla (author)
- Sandberg, Yorick (author)
- Vojdeman, Fie Juhl (author)
- Boudjogra, Myriam (author)
- Tzenou, Tatiana (author)
- Chatzouli, Maria (author)
- Chu, Charles C (author)
- Veronese, Silvio (author)
- Gardiner, Anne (author)
- Pedersen, Lone Bredo (author)
- Moreno, Denis (author)
- Van Lom, Kirsten (author)
- Giudicelli, Véronique (author)
- Francova, Hana Skuhrova (author)
- Nguyen-Khac, Florence (author)
- Panagiotidis, Panagiotis (author)
- Angelis, Lefteris (author)
- Anagnostopoulos, Achilles (author)
- Lefranc, Marie-Paule (author)
- Facco, Monica (author)
- Trentin, Livio (author)
- Catherwood, Mark (author)
- Montillo, Marco (author)
- Geisler, Christian H (author)
- Langerak, Anton W (author)
- Pospisilova, Sarka (author)
- Chiorazzi, Nicholas (author)
- Oscier, David (author)
- Jelinek, Diane F (author)
- Darzentas, Nikos (author)
- Belessi, Chrysoula (author)
- Davi, Frederic (author)
- Ghia, Paolo (author)
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- (creator_code:org_t)
- American Society of Hematology, 2015
- 2015
- English.
- In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 125:5, s. 856-859
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non-subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P = .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non-subset #2/IGHV3-21 (22 vs 60 months, P = .001). No such difference was observed between non-subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non-subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- Blood
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