id:"swepub:oai:lup.lub.lu.se:b065f81f-6cd4-4608-b75f-6612e9b82d2b"
Search: id:"swepub:oai:lup.lub.lu.se:b065f81f-6cd4-4608-b75f-6612e9b82d2b" > Regulation of Blood...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Dahlbäck, BjörnLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups (author)
Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway. Novel Insights Into Structure-Function Relationships and Molecular Recognition.
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- 2005
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:b065f81f-6cd4-4608-b75f-6612e9b82d2b
- https://lup.lub.lu.se/record/138256URI
- https://doi.org/10.1161/01.ATV.0000168421.13467.82DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The protein C system provides important control of blood coagulation by regulating the activities of factor VIIIa (FVIIIa) and factor Va(FVa), cofactors in the activation of factor X and prothrombin, respectively. The system comprises membrane-bound and circulating proteins that assemble into multi-molecular complexes on cell surfaces. Vitamin K-dependent protein C, the key component of the system, circulates in blood as zymogen to an anticoagulant serine protease. It is efficiently activated on the surface of endothelial cells by thrombin bound to the membrane protein thrombomodulin. The endothelial protein C receptor (EPCR) further stimulates the protein C activation. Activated protein C (APC) together with its cofactor protein S inhibits coagulation by degrading FVIIIa and FVa on the surface of negatively charged phospholipid membranes. Efficient FVIIIa degradation by APC requires not only protein S but also intact FV, which like thrombin is a Janus-faced protein with both procoagulant and anticoagulant potential. In addition to its anticoagulant properties, APC has antiinflammatory and antiapoptotic functions, which are exerted when APC binds to EPCR and proteolytic cleaves protease-activated receptor 1 (PAR-1). The protein C system is physiologically important, and genetic defects affecting the system are the most common risk factors of venous thrombosis. The proteins of the protein C system are composed of multiple domains and the 3-dimensional structures of several of the proteins are known. The molecular recognition of the protein C system is progressively being unraveled, giving us new insights into this fascinating and intricate molecular scenario at the atomic level.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- thrombomodulin
- factor V
- protein C
- protein S
Added entries (persons, corporate bodies, meetings, titles ...)
- Villoutreix, Bruno O (author)
- Klinisk kemi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:Arteriosclerosis, Thrombosis and Vascular Biology25:7, s. 1311-13201524-4636
Internet link
Find in a library
- Arteriosclerosis, Thrombosis and Vascular Biology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Dahlbäck, Björn
- Villoutreix, Bru ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- Arteriosclerosis ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
