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International Socie...
International Society of Urological Pathology Expert Opinion on Grading of Urothelial Carcinoma
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- van der Kwast, Theo (author)
- Princess Margaret Hospital University of Toronto
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- Liedberg, Fredrik (author)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Black, Peter C. (author)
- University of British Columbia
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- Kamat, Ashish (author)
- University of Texas MD Anderson Cancer Center
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- van Rhijn, Bas W.G. (author)
- Antoni Van Leeuwenhoek Hospital
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- Algaba, Ferran (author)
- Autonomous University of Barcelona
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- Berman, David M. (author)
- Queen's University at Kingston
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- Hartmann, Arndt (author)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Lopez-Beltran, Antonio (author)
- University of Córdoba, Spain
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- Samaratunga, Hemamali (author)
- University of Queensland,Aquesta Uropathology
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- Varma, Murali (author)
- University Hospital of Wales
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- Cheng, Liang (author)
- Indiana University
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: European Urology Focus. - : Elsevier BV. - 2405-4569. ; 8:2, s. 438-446
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Context: Grading is the mainstay for treatment decisions for patients with non–muscle-invasive bladder cancer (NMIBC). Objective: To determine the requirements for an optimal grading system for NMIBC via expert opinion. Evidence acquisition: A multidisciplinary working group established by the International Society of Urological Pathology reviewed available clinical, histopathological, and molecular evidence for an optimal grading system for bladder cancer. Evidence synthesis: Bladder cancer grading is a continuum and five different grading systems based on historical grounds could be envisaged. Splitting of the World Health Organization (WHO) 2004 low-grade class for NMIBC lacks diagnostic reproducibility and molecular-genetic support, while showing little difference in progression rate. Subdividing the clinically heterogeneous WHO 2004 high-grade class for NMIBC into intermediate and high risk categories using the WHO 1973 grading is supported by both clinical and molecular-genetic findings. Grading criteria for the WHO 1973 scheme were detailed on the basis of literature findings and expert opinion. Conclusions: Splitting of the WHO 2004 high-grade category into WHO 1973 grade 2 and 3 subsets is recommended. Provision of more detailed histological criteria for the WHO 1973 grading might facilitate the general acceptance of a hybrid four-tiered grading system or—as a preferred option—a more reproducible three-tiered system distinguishing low-, intermediate (high)-, and high-grade NMIBC. Patient summary: Improvement of the current systems for grading bladder cancer may result in better informed treatment decisions for patients with bladder cancer. A three-tiered grading system for non–muscle invasive bladder cancer derived by splitting the heterogeneous World Health Organization (WHO) 2004 high-grade category into WHO 1973 grade 2 and 3 subsets is recommended, as this may result in more informed treatment decisions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Bladder cancer
- Expert opinion
- Grading system
- Non-muscle invasive bladder cancer
- Pathology
- WHO 1973
- WHO 2004
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- for (subject category)
- ref (subject category)
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- By the author/editor
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van der Kwast, T ...
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Liedberg, Fredri ...
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Black, Peter C.
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Kamat, Ashish
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van Rhijn, Bas W ...
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Algaba, Ferran
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show more...
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Berman, David M.
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Hartmann, Arndt
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Lopez-Beltran, A ...
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Samaratunga, Hem ...
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Varma, Murali
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Cheng, Liang
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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European Urology ...
- By the university
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Lund University