Search: WFRF:(Sokal Adam) >
Acute Hemodynamic E...
Acute Hemodynamic Effects of Simultaneous and Sequential Multi-Point Pacing in Heart Failure Patients With an Expected Higher Rate of Sub-response to Cardiac Resynchronization Therapy : Results of Multicenter SYNSEQ Study
-
- Sterliński, Maciej (author)
- Cardinal Wyszynski National Institute of Cardiology
-
- Zakrzewska-Koperska, Joanna (author)
- Cardinal Wyszynski National Institute of Cardiology
-
- Maciąg, Aleksander (author)
- Cardinal Wyszynski National Institute of Cardiology
-
show more...
-
- Sokal, Adam (author)
- Silesian Center of Heart Disease
-
- Osca-Asensi, Joaquin (author)
- University and Polytechnic Hospital la Fe
-
- Wang, Lingwei (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Arrhytmias and Cardiac Device treatment,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
-
- Spyropoulou, Vasiliki (author)
- Medtronic Bakken Research Center, Maastricht
-
- Maus, Baerbel (author)
- Medtronic Bakken Research Center, Maastricht
-
- Lemme, Francesca (author)
- Medtronic Bakken Research Center, Maastricht
-
- Okafor, Osita (author)
- University of Birmingham
-
- Stegemann, Berthold (author)
- Aston University
-
- Cornelussen, Richard (author)
- Medtronic Bakken Research Center, Maastricht
-
- Leyva, Francisco (author)
- Aston University
-
show less...
-
(creator_code:org_t)
- 2022-05-12
- 2022
- English.
-
In: Frontiers in Cardiovascular Medicine. - : Frontiers Media SA. - 2297-055X. ; 9, s. 1-10
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- The aim of the SYNSEQ (Left Ventricular Synchronous vs. Sequential MultiSpot Pacing for CRT) study was to evaluate the acute hemodynamic response (AHR) of simultaneous (3P-MPP syn) or sequential (3P-MPP seq) multi-3-point-left-ventricular (LV) pacing vs. single point pacing (SPP) in a group of patients at risk of a suboptimal response to cardiac resynchronization therapy (CRT). Twenty five patients with myocardial scar or QRS ≤ 150 or the absence of LBBB (age: 66 ± 12 years, QRS: 159 ± 12 ms, NYHA class II/III, LVEF ≤ 35%) underwent acute hemodynamic assessment by LV + dP/dtmax with a variety of LV pacing configurations at an optimized AV delay. The change in LV + dP/dt max (%ΔLV + dP/dt max) with 3P-MPP syn (15.6%, 95% CI: 8.8%-22.5%) was neither statistically significantly different to 3P-MPP seq (11.8%, 95% CI: 7.6-16.0%) nor to SPP basal (11.5%, 95% CI:7.1-15.9%) or SPP mid (12.2%, 95% CI:7.9-16.5%), but higher than SPP apical (10.6%, 95% CI:5.3-15.9%, p = 0.03). AHR (defined as a %ΔLV + dP/dt max ≥ 10%) varied between pacing configurations: 36% (9/25) for SPP apical, 44% (11/25) for SPP basal, 54% (13/24) for SPP mid, 56% (14/25) for 3P-MPP syn and 48% (11/23) for 3P-MPP seq.Fifteen patients (15/25, 60%) had an AHR in at least one pacing configuration. AHR was observed in 10/13 (77%) patients with a LBBB but only in 5/12 (42%) patients with a non-LBBB (p = 0.11). To conclude, simultaneous or sequential multipoint pacing compared to single point pacing did not improve the acute hemodynamic effect in a suboptimal CRT response population.Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT02914457.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sterliński, Maci ...
-
Zakrzewska-Koper ...
-
Maciąg, Aleksand ...
-
Sokal, Adam
-
Osca-Asensi, Joa ...
-
Wang, Lingwei
-
show more...
-
Spyropoulou, Vas ...
-
Maus, Baerbel
-
Lemme, Francesca
-
Okafor, Osita
-
Stegemann, Berth ...
-
Cornelussen, Ric ...
-
Leyva, Francisco
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Frontiers in Car ...
- By the university
-
Lund University